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Structural basis of tethered agonism and G protein coupling of protease-activated receptors
Protease-activated receptors (PARs) are a unique group within the G protein-coupled receptor superfamily, orchestrating cellular responses to...
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Identification and functional analysis of long non-coding RNA (lncRNA) and metabolites response to mowing in hulless barley (Hordeum vulgare L. var. nudum hook. f.)
BackgroundHulless barley ( Hordeum vulgare L. var. nudum Hook. f.) is a significant cereal crop and a substantial source of forage for livestock....
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here...
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Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Arthropod-borne pathogens are responsible for hundreds of millions of infections in humans each year. The blacklegged tick, Ixodes scapularis , is the...
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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications
Approved vaccines are effective against severe COVID-19, but broader immunity is needed against new variants and transmission. Therefore, we...
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Neutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We...
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The potential application of Czenspinskia transversostriata in biological control
Phytoseiid predatory mites are one of the most important groups of biocontrol agents, commonly used in biological control. The ability to produce...
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Thiolated chitosan nanoparticles encapsulated nisin and selenium: antimicrobial/antibiofilm/anti-attachment/immunomodulatory multi-functional agent
BackgroundThe increase in the resistance of bacterial strains to antibiotics has led to research into the bactericidal potential of non-antibiotic...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Traditional Herbal Remedies Used in the Management of Urolithiasis by the Tribals of Purulia District, West Bengal, India
The tribal populations in Purulia district directly or indirectly rely on medicinal plants for their basic medical needs. Urolithiasis is the...
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Identification and characterization of specific motifs in effector proteins of plant parasites using MOnSTER
Plant pathogens cause billions of dollars of crop loss every year and are a major threat to global food security. Identifying and characterizing...
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Long-term change in the tree community of a tropical forest remnant surrounded by human-modified landscapes
Previous studies have demonstrated that the tree community of small and isolated forest fragments show persisting structural and functional...
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Restoration of degraded alpine meadows from the perspective of plant–soil feedbacks
Understanding the plant–soil feedbacks (PSFs) of dominant species of alpine meadow under different degradation status could provide insights into...
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Effect of agricultural management system (“cash crop”, “livestock” and “climate optimized”) on nitrous oxide and ammonia emissions
The study aimed to measure soil-atmosphere N 2 O fluxes and their controlling factors, as well as NH 3 emissions and yields for two soils (silt loam and...
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Exploring the variation in α-amylase activity and thermostability in green malt of diverse barley (Hordeum vulgare L.) germplasm
This study investigated the activity and thermostability of α-amylase in green malt across a diverse panel of 54 barley genotypes, comprising 20...
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Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics
Keypoint tracking algorithms can flexibly quantify animal movement from videos obtained in a wide variety of settings. However, it remains unclear...
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Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
Immunoglobulins (Ig), which exist either as B-cell receptors (BCR) on the surface of B cells or as antibodies when secreted, play a key role in the...
