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Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses
Previous studies on age-related changes in cortical and hippocampal morphology were not designed or able to reveal the complex spatial patterns of...
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Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy
Excessive growth hormone (GH) has been shown to promote joint degeneration in both preclinical and clinical studies. Little is known about the effect...
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Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study
Considerable uncertainty remains regarding the associations of multiple factors with brain health. We aimed to conduct an exposome-wide association...
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The companion dog as a model for inflammaging: a cross-sectional pilot study
Inflammaging, the chronic, progressive proinflammatory state associated with aging, has been associated with multiple negative health outcomes in...
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Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
The extent to which the neural systems underlying semantic processes degrade with advanced age remains unresolved, which motivated the current study...
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Lifespan regulation by targeting heme signaling in yeast
Heme is an essential prosthetic group that serves as a co-factor and a signaling molecule. Heme levels decline with age, and its deficiency is...
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Enhancing the human health and lifespan: a targeted strategy emphasizing statins
There has been substantial research interest in finding activities/agents that slow the onset and reduce the severity of numerous age-related...
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Compensation effect of mortality is a challenge to substantial lifespan extension of humans
Despite frequent claims regarding radical extensions of human lifespan in the near future, many pragmatic scientists caution against excessive and...
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Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and incident dementia: The UK Biobank study
The plasma proteome can mediate poor oral health problems (POHP)’s link to incident dementia. We screened 37,269 UK Biobank participants 50–74 years...
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Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults
This study examined the association between in vivo skeletal mitochondrial function and digital free-living physical activity patterns—a measure that...
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Metacognition in Japanese macaques (Macaca fuscata): does impulsivity explain unnecessary looks in the tubes task?
Potential metacognitive abilities, such as monitoring and controlling cognitive processes, have been revealed in some primate species. In the tubes...
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Hypothalamic sex-specific metabolic shift by canagliflozin during aging
The hypothalamus undergoes significant changes with aging and plays crucial roles in age-related metabolic alterations. Sodium-glucose co-transporter...
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Facilitation of working memory capacity by transcranial direct current stimulation: a secondary analysis from the augmenting cognitive training in older adults (ACT) study
Aging is a public health concern with an ever-increasing magnitude worldwide. An array of neuroscience-based approaches like transcranial direct...
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Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats
Aging is accompanied by an increased prevalence of degenerative conditions, including those affecting ocular health, which significantly impact...
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Avidity maturation of humoral response following primary and booster doses of BNT162b2 mRNA vaccine among nursing home residents and healthcare workers
Infections, despite vaccination, can be clinically consequential for frail nursing home residents (NHR). Poor vaccine-induced antibody quality may...
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Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidence found that it is a strong...
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Perception of optical illusions in ungulates: insights from goats, sheep, guanacos and llamas
Optical illusions have long been used in behavioural studies to investigate the perceptual mechanisms underlying vision in animals. So far, three...
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Fmo induction as a tool to screen for pro-longevity drugs
Dietary restriction (DR) and hypoxia (low oxygen) extend lifespan in Caenorhabditis elegans through the induction of a convergent downstream...
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Nest excavators’ learning walks in the Australian desert ant Melophorus bagoti
The Australian red honey ant, Melophorus bagoti , stands out as the most thermophilic ant in Australia, engaging in all outdoor activities during the...
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Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study
The study evaluated how ingestion of nicotinamide mononucleotide (NMN) for 12 weeks by older adults affected blood nicotinamide adenine dinucleotide...
