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PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic...
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In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme...
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Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls
Creatine is a natural nitrogenous organic acid that is integral to energy metabolism and crucial for proper cell functioning. The kidneys are...
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Combined assessment of lysine and N-acetyl cadaverine levels assist as a potential biomarker of the smoker periodontitis
Periodontitis is an inflammatory condition of supporting structures of teeth leading to attachment and bone loss. Cigarette smoking is the single...
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A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate
Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive...
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Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique
Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique...
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Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study
Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known...
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Therapeutic peptides for coronary artery diseases: in silico methods and current perspectives
Many drug formulations containing small active molecules are used for the treatment of coronary artery disease, which affects a significant part of...
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Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis
In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease...
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The use of peptides for immunodiagnosis of human Chagas disease
Chagas disease, caused by the protozoa Trypanosoma cruzi , continues to be a serious public health problem in Latin America, worsened by the...
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pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells
Breast cancer is the most common cancer among women worldwide, and marine creatures are the most abundant reservoir of anticancer medicines....
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Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular...
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Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
Diabetic neuropathy (DN) is a common neurological complication caused by diabetes mellitus (DM). Axonal degeneration is generally accepted to be the...
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Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a form of severe acute stroke with very high mortality and disability rates. Early brain injury (EBI) and delayed...
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Effects of cancer-induced cachexia and administration of l-glutathione on the intestinal mucosa in rat
Walker-256 tumor is an experimental model known to promote cachexia syndrome, oxidative stress, and systemic inflammation. This study evaluated the...
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Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
L-theanine, an amino acid component of the tea leaves of Camellia sinensis , is sold in Japan as a supplement for good sleep. Although several studies...
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Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens
In the face of increasing antimicrobial resistance in aquaculture, researchers are exploring novel substitutes to customary antibiotics. One...
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Superior bioavailability of the calcium salt form of β-hydroxy-β-methylbutyrate compared with the free acid form
We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of β-hydroxy-β-methylbutyrate (HMB). Sixteen young...
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Reductive amination of ω-conotoxin MVIIA: synthesis, determination of modification sites, and self-assembly
Peptide drugs have disadvantages such as low stability, short half-life and side effects, which limit their widespread use in clinical practice....
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Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Nowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the...
