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Advances in development of biomarkers for brain damage and ischemia
Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. Magnetic resonance imaging (MRI) and computed tomography...
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A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1–a stem-like cells in the presence and absence of insulin
BackgroundAcute Myeloid Leukemia (AML) is a fast-develo** invading cancer that impacts the blood and bone marrow, marked by the rapid proliferation...
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The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway
BackgroundIdiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by a constant incidence rate. Unfortunately, effective...
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Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women
BackgroundRecurrent miscarriage (RM) is defined as the occurrence of at least two or three subsequent miscarriages within the 20th -24th weeks of...
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Loop-mediated isothermal amplification (LAMP) assay for early on-site detection of Group B Streptococcus infection in neonatal sepsis blood sample
BackgroundNeonatal sepsis, often attributed to Group B Streptococcus (GBS) infection, poses a critical health risk to infants, demanding rapid and...
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Immunodetection of tubulin and centromeric histone H3 (CENH3) proteins in Glycine species
BackgroundThe centromeres appear as primary constrictions on monocentric metaphase chromosomes; where sister chromatids are held together and...
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Evaluating the expression pattern of ATXN1 and CDC42EP1 genes and related long noncoding RNAs in oral squamous cell carcinoma
BackgroundOral squamous cell carcinoma (OSCC) is a significant health issue worldwide, and the expression of long non-coding RNAs (lncRNAs) are...
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Suppression of CTC1 inhibits hepatocellular carcinoma cell growth and enhances RHPS4 cytotoxicity
BackgroundAlthough DNA repair mechanisms function to maintain genomic integrity, in cancer cells these mechanisms may negatively affect treatment...
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Multiplex PCR-based genoty** of Salmonella Enteritidis and Salmonella Typhimurium from food sources and assessment of their antimicrobial resistance profiles in Egypt
BackgroundSalmonellosis is a widespread zoonotic disease that poses a significant threat to livestock and public health. This study aimed to serotype...
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Molecular identification and GC-MS analysis of a newly isolated novel bacterium (Lysinibacillus sp. VCRC B655) for mosquito control
BackgroundMosquitoes are widespread globally and have contributed to transmitting pathogens to humans and the burden of vector-borne diseases. They...
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β-Hydroxybutyrate and melatonin suppress maladaptive UPR, excessive autophagy and pyroptosis in Aβ 1–42 and LPS-Induced SH-SY5Y cells
BackgroundAlzheimer’s disease is a neurological disease characterized by the build-up of amyloid beta peptide (Aβ) and lipopolysaccharide (LPS),...
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Up-regulation of miR-126 via DNA methylation in hypoxia-preconditioned endothelial cells may contribute to hypoxic tolerance of neuronal cells
BackgroundEndothelial cells (ECs) can confer neuroprotection by secreting molecules. This study aimed to investigate whether DNA methylation...
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Regulation of MicroRNA-4697-3p by Parkinson’s disease-associated SNP rs329648 and its impact on SNCA112 mRNA
BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder characterized by a multifaceted genetic foundation. Genome-Wide Association...
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Genetic components of microdeletion syndromes and their role in determining schizophrenia traits
Schizophrenia is a neuropsychiatric disorder characterized by various symptoms such as hallucinations, delusions, and disordered thinking. The...
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Assessment of ID family proteins expression in colorectal cancer of Iraqi patients
BackgroundColorectal cancer (CRC) is the second most deathly worldwide and third most common cancer, CRC is a very heterogeneous disease where tumors...
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Research progress on differentiation and regulation of plant chromoplasts
Carotenoids, natural tetraterpenoids found abundantly in plants, contribute to the diverse colors of plant non-photosynthetic tissues and provide...
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Regulation of Keap1-Nrf2 signaling in health and diseases
Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a central regulator in modulating the activities of diverse antioxidant enzymes,...
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Chlorogenic acid mitigates potassium dichromate-induced acute hepato-nephrotoxicity by attenuating the NF-κB signalling pathway
BackgroundHexavalent chromium (CrVI) is known to be a potentially hepatotoxic and nephrotoxic contaminant in humans and other animals, whose toxicity...
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5-mC methylation study of sORFs in 3ˈUTR of transcription factor JUNGBRUNNEN 1-like during leaf rust pathogenesis in wheat
BackgroundJUB1, a NAC domain containing hydrogen peroxide-induced transcription factor, plays a critical role in plant immunity. Little is known...
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Modifiable risk factors, oxidative stress markers, and SOD2 rs4880 SNP in coronary artery disease: an association study
BackgroundCoronary artery disease (CAD) has been linked to single nucleotide polymorphism (SNP) in superoxide dismutase 2 (SOD 2) gene. Additionally,...
