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Designing a novel and combinatorial multi-antigenic epitope-based vaccine “MarVax” against Marburg virus—a reverse vaccinology and immunoinformatics approach
ContextMarburg virus (MARV) is a member of the Filoviridae family and causes Marburg virus disease (MVD) among humans and primates. With fatality...
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Structural and functional characterization of a hypothetical protein in the RD7 region in clinical isolates of Mycobacterium tuberculosis — an in silico approach to candidate vaccines
BackgroundMycobacterium tuberculosis has been ravaging humans by inflicting respiratory tuberculosis since centuries. Bacillus Calmette Guerine...
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Analysis of the Confidence in the Prediction of the Protein Folding by Artificial Intelligence
The determination of protein structure has been facilitated using deep learning models, which can predict protein folding from protein sequences. In...
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Characterization, protein modeling, and molecular docking of factor C from Indonesian horseshoe crab (Tachypleus gigas)
BackgroundHorseshoe crab ( Tachypleus gigas ) amebocytes are useful biomedical components for endotoxin detection, and their growing needs for...
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Production of codon-optimized Factor C fragment from Tachypleus gigas in the Pichia pastoris GS115 expression system for endotoxin detection
BackgroundFactor C (FC) is widely used as a standard material for endotoxin testing. It functions as a zymogenic serine protease and serve as a...
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In silico analysis of HLA-1 and HLA-2 recognition of a designed recombinant human papillomavirus vaccine based on L1 protein HPV subtype 45
BackgroundHuman leukocyte antigen (HLA) can bind and present the processed antigenic peptide derived from the vaccine to the T cell receptor, and...
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Map** of conserved immunodominant epitope peptides in the outer membrane porin (Omp) L of prominent Enterobacteriaceae pathogens associated with gastrointestinal infections
BackgroundMembers of Enterobacteriaceae such as Escherichia coli O 157:H7, Salmonella sp., Shigella sp., Klebsiella sp., and Citrobacter freundii ...
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Molecular Modeling Techniques and In-Silico Drug Discovery
Molecular modeling is the technique to determine the overall structure of an unknown molecule, be it a small one or a macromolecule. The technique...
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From Genomes to Variant Interpretations Through Protein Structures
The large amount of genetic, phenotypic, and structural data from diverse conditions and environments offers opportunities for new groundbreaking...
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Improved protein structure prediction by deep learning irrespective of co-evolution information
Predicting the tertiary structure of a protein from its primary sequence has been greatly improved by integrating deep learning and co-evolutionary...
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Functional annotation of an ecologically important protein from Chloroflexus aurantiacus involved in polyhydroxyalkanoates (PHA) biosynthetic pathway
Chloroflexus aurantiacus J-10-fI strain is a thermophilic gram-negative bacterium that possesses many proteins in its genome; some are considered as...
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Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silico
As the body of scientific research focusing on the severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 continues to grow, several mutations...
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Nanobiosensors: A powerful Technology for Early Detection of Plant Parasitic Nematodes
Nanotechnology emerged as a critical force in agriculture and the most vital technology. Nanobiotechnology offers significant benefits for farmers...
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Computational Intelligence Tools for Protein Modeling
Protein modeling plays a quite important role in computational aid drug discovery and designing. Advancements in computational tools make easy to...
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Develo** COVID-19 Vaccines by Innovative Bioinformatics Approaches
COVID-19 is an acute infectious respiratory novel coronavirus disease. The infection is caused by SARS-CoV-2 (severe acute respiratory syndrome...
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Computational Methods Used in Prediction of Protein Structure
This work represents the prediction of protein structures through computational approaches. The advanced tools for computational method are majorly...
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A Study on Protein Structure Prediction
Prediction of protein structure is one of the key research areas in bioinformatics. These identified structures can be used in the development of...
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Protein Folding Problem in the Case of Peptides Solved by Hybrid Simulated Annealing Algorithms
Protein Folding Problem (PFP) is a computational challenge with many implications in bioinformatics and computer science. This problem consists in...
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Rational Designing of Novel Proteins Through Computational Approaches
Advances in the computational power has bestowed us with several structural bioinformatics tools that one can utilize them to predict the...
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Human Fibroblast Growth Factor 2 Hot Spot Analysis by Means of Time-Frequency Transforms
Energy in protein complexes is not uniformly distributed. Some ofTamulewicz, Anna@Tamulewicz, Anna Tkacz, Ewaryst@Tkacz, Ewaryst...