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Computational design and evaluation of mRNA- and protein-based conjugate vaccines for influenza A and SARS-CoV-2 viruses
BackgroundIsrael confirmed the first case of “flurona”—a co-infection of seasonal flu (IAV) and SARS-CoV-2 in an unvaccinated pregnant woman. This...
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Probik: Protein Backbone Motion by Inverse Kinematics
To investigate the parameters of the protein design problem that we are exploring in collaboration with biochemists, we developed a tool that uses...
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Production of codon-optimized Factor C fragment from Tachypleus gigas in the Pichia pastoris GS115 expression system for endotoxin detection
BackgroundFactor C (FC) is widely used as a standard material for endotoxin testing. It functions as a zymogenic serine protease and serve as a...
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In silico design and evaluation of multi-epitope dengue virus vaccines: a promising approach to combat global dengue burden
Dengue virus, a pervasive mosquito-borne pathogen, imposes a substantial global health burden and is responsible for numerous fatalities annually...
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Structural and functional characterization of a hypothetical protein in the RD7 region in clinical isolates of Mycobacterium tuberculosis — an in silico approach to candidate vaccines
BackgroundMycobacterium tuberculosis has been ravaging humans by inflicting respiratory tuberculosis since centuries. Bacillus Calmette Guerine...
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Design of a multi-epitope vaccine against the pathogenic fungi Candida tropicalis using an in silico approach
BackgroundCandida tropicalis causes tropical invasive fungal infections, with a high mortality. This fungus has been found to be resistant to...
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Plant catalase in silico characterization and phylogenetic analysis with structural modeling
BackgroundCatalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It...
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Improved collision handling of elastic solids in sph using a contact force model
Modeling of collision between elastic solids involves deformation of bodies and the interaction with other bodies. Classically, smoothed particle...
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In silico characterization of the GH5-cellulase family from uncultured microorganisms: physicochemical and structural studies
BackgroundHydrolysis of cellulose-based biomass by cellulases produce fermented sugar for making biofuels, such as bioethanol. Cellulases hydrolyze...
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In silico targeting of red complex bacteria virulence factors of periodontitis with β-defensin 1
BackgroundPeriodontitis is a multi-factorial infection with red complex bacteria playing a crucial role in the pathogenesis. As bacteria are tending...
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In silico Structural, Functional and Phylogenetic Analyses of cellulase from Ruminococcus albus
BackgroundCellulose is the primary component of the plant cell wall and an important source of energy for the ruminant and microbial protein...
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In silico modelling and characterization of eight blast resistance proteins in resistant and susceptible rice cultivars
BackgroundNucleotide-binding site-leucine-rich repeat (NBS-LRR) resistance genes are the largest class of plant resistance genes which play an...
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SVM Based Vibration Analysis for Effective Classification of Machine Conditions
In condition monitoring, alarms have been the significant references for assessment of critical conditions. Generation of false alarms or suppression...
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In silico characterization and structural modeling of bacterial metalloprotease of family M4
BackgroundThe M4 family of metalloproteases is comprised of a large number of zinc-containing metalloproteases. A large number of these enzymes are...
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Exploration of Rhinacanthone, a Natural Naphthoquinone, as a Potential Human Papilloma Virus E7 Oncoprotein Inhibitor (HPV-E7i) Through AI-Based Protein Modeling, Molecular Docking, and Simulation Studies
For more than three decades, cervical cancer has been linked to the Human Papillomavirus, yet there is currently no effective therapy for Human...
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In Silico Modeling and Screening Studies of PfRAMA Protein: Implications in Malaria
Malaria is a major parasitic disease that affects a large human population, especially in tropical and sub-tropical countries. The treatment of...
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Exploring structural antigens of yellow fever virus to design multi-epitope subunit vaccine candidate by utilizing an immuno-informatics approach
BackgroundYellow fever is a mosquito-borne viral hemorrhagic disease transmitted by several species of virus-infected mosquitoes endemic to tropical...
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A Bayesian Approach to Determinants of Capital Structure of Listed Construction Firms in Vietnam
This study aims to find out the factors affecting the capital structure of construction enterprises listed in Vietnam Stock Exchange in the period...
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Mathematical analysis for resonant frequencies of a novel 3-element log periodic patch array
This composition elucidates a mathematical investigation of a novel printed log periodic array where the number of elements is 3 and each element has...
