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Response surface optimization design of flexible positioning platform considering its fatigue life
The research of macro and micro motion platforms has always been committed to realizing the ultra-high acceleration operation of the platform and...
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Detection of Ochratoxin A Mycotoxin with Graphene Nanosheets Functionalized with Selective Peptides Using Molecular Dynamics
Ochratoxin A (OTA) is a mycotoxin commonly found in improperly stored grains, posing significant risks to food safety. Accurate detection of this...
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Evaluation of Stiffness Loss Indicators Using Displacement Influence Lines for Homogeneous Beams
In this work, the simple beam and continuous beam with two spans—two popular types of beam structures—were examined under various conditions to... -
Bone-Implant Osseointegration Monitoring Using Electro-mechanical Impedance Technique and Convolutional Neural Network: A Numerical Study
Accurate quantification of the jawbone-implant interface plays a pivotal role in assessing the mechanical stability of dental implant structures....
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Learning-Forgetting-Fatigue-Recovery Simulation Model
The present research aims to correlate the performance loss of a worker and fatigue during a day-work journey of a maintenance routine. The... -
Drug Discovery with Computational Intelligence Against COVID-19
Since the advent of the current pandemic of corona virus-induced disease in December 2019 to date, the search for knowledge has specifically been... -
Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay
BackgroundMondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves...
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An In-Situ, Micro-Mechanical Setup with Accurate, Tri-Axial, Piezoelectric Force Sensing and Positioning
To enable accurate characterization of the mechanical behavior of materials at the micro-scale, e.g., in micro-systems, experiments are required that...
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis
BackgroundAccessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring...
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Cold-Flow Investigation of the Darmstadt Engine with Focus on Statistical Convergence: Experimental and Large Eddy Simulation Analysis
The paper analyses particle image velocimetry (PIV) measurements and multi-cycle Large Eddy Simulation (LES) of the in-cylinder flow of the...
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Fatigue Damage Identification and Remaining Useful Life Estimation of Composite Structures Using Piezo Wafer Active Transducers
The prediction of fatigue damage accumulation is a crucial element in the estimation of the Remaining Useful Life of composite structures subjected... -
Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study
BackgroundHypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement...
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Impedance-Based PZT Transducer and Fuzzy Logic to Detect Damage in Multi-point Dressers
Alternative techniques such as impedance-based lead zirconate titanate (PZT) transducers has emerged as an innovative approach for manufacturing... -
Optimizing ligand conformations in flexible protein targets: a multi-objective strategy
Finding the orientation of a ligand (small molecule) with the lowest binding energy to the macromolecule (receptor) is a complex optimization...
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Evaluation of CFD turbulence models for simulating external airflow around varied building roof with wind tunnel experiment
Detailed airflow information around a building can be crucial for the design of naturally ventilated systems and for exhaust air dispersion practices...
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Comparison of Backstep**-Based Sliding Mode and Adaptive Backstep** for a Robust Control of a Twin Rotor Helicopter
In this contribution, two robust MIMO backstep** control approaches for a twin rotor aerodynamic system (TRAS) test-rig are considered. The TRAS... -
Per-Residue Energy Footprints-Based Pharmacophore Modeling as an Enhanced In Silico Approach in Drug Discovery: A Case Study on the Identification of Novel β-Secretase1 (BACE1) Inhibitors as Anti-Alzheimer Agents
A further refinement to our previously published “target-bound pharmacophore modeling approach” is reported herein. Instead of relying on “random”...
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On the Bias of the SIR Filter in Parameter Estimation of the Dynamics Process of State Space Models
As a popular nonlinear estimation tool, the sampling importance resampling (SIR) filter has been applied with the expectation–maximization (EM)... -
Fault detection of composite beam by using the modal parameters and RBFNN technique
The detection of transverse cracks in terms of their location and intensity by using the radial basis function neural network (RBFNN) technique is...
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The Electromechanical Impedance Method and its Application for Paint Coating Damage Detection
This paper reports research findings of a corrosion sensing project for applying the electromechanical impedance method for paint coating damage...