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Influence of Porocoat Beaded Coating Structure on Bone Ingrowth Around the Porous Coated Implant: A Two-Dimensional Finite Element Study
The long-term biomechanical functionality of uncemented orthopaedic implants relies on bone ingrowth around porous coated implants. The present study...
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A comprehensive analysis of bio-inspired design of femoral stem on primary and secondary stabilities using mechanoregulatory algorithm
The coated porous section of stem surface is initially filled with callus that undergoes osseointegration process, which develops a bond between stem...
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Neural Network (NN) Based Qualitative Assessment of Bone Growth Over Textured Implant Surfaces
ImplantsNeural Networks are widely used in the restoration of failed joints and bone fractures across the globe. The success of an orthopaedic...
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Image-based radiodensity profilometry measures early remodeling at the bone-callus interface in sheep
Bone healing has been traditionally described as a four-phase process: inflammatory response, soft callus formation, hard callus development, and...
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Combined Influence of Material Properties of Bone and Implant on Bone Growth Over Macro-Textured Implant Surface
Cementless implants have attracted greater research attention than cemented implants, owing to the longer term biologic attachment they provide...
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Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks
During Achilles tendon healing in rodents, besides the expected tendon tissue, also cartilage-, bone- and fat-like tissue features have been observed...
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An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering
Recently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells...
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The Relevance of Biomechanical Analysis in Joint Replacements: A Review
Biomechanical analysis, numerical and experimental, has been extensively used for more than 3 decades to investigate the mechanical behaviour of bone...
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Computational modeling reveals inflammation-driven dilatation of the pulmonary autograft in aortic position
The pulmonary autograft in the Ross procedure, where the aortic valve is replaced by the patient’s own pulmonary valve, is prone to failure due to...
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Mechanoregulation modeling of bone healing in realistic fracture geometries
In bone fracture healing, new tissue gradually forms, ossifies, and eventually remodels itself to restore mechanical stiffness and strength across...
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Shear Stress in Bone Marrow has a Dose Dependent Effect on cFos Gene Expression in In Situ Culture
IntroductionMechanical stimulation of bone is necessary to maintain its mass and architecture. Osteocytes within the mineralized matrix are sensors...
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A mechano-chemo-biological model for bone remodeling with a new mechano-chemo-transduction approach
Bone remodeling is a fundamental biological process that develops in bone tissue along its whole lifetime. It refers to a continuous bone...
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Bone ingrowth around porous-coated acetabular implant: a three-dimensional finite element study using mechanoregulatory algorithm
Fixation of uncemented implant is influenced by peri-prosthetic bone ingrowth, which is dependent on the mechanical environment of the implant–bone...
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Simulation of extracellular matrix remodeling by fibroblast cells in soft three-dimensional bioresorbable scaffolds
To culture functional soft tissues and organs in three-dimensional scaffolds, it is essential to elucidate the optimal scaffold mechanical...
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Simulated bone remodeling around tilted dental implants in the anterior maxilla
Dental implants have to be placed with the long axis in different angulations due to the change in bone morphology. The objective of this study was...
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Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur
Bone morphology and density changes are commonly observed following joint replacement, may contribute to the risks of implant loosening and...
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Computational prediction of strain-dependent diffusion of transcription factors through the cell nucleus
Nuclear spreading plays a crucial role in stem cell fate determination. In previous works, we reported evidence of multipotency maintenance for...
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Mechano-regulation theory-based finite element analysis on the effects of driving strain history on cellular differentiation
The aim of this study was to determine the appropriate driving strain history of a dynamic cell culture device for inducing accelerated cell...
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Computer-Aided Tissue Engineering: Application to the Case of Anterior Cruciate Ligament Repair
Tissue engineering has the potential to overcome the limitations associated with current reconstructions strategies of the Anterior Cruciate Ligament...
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Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissue Structure
This chapter gives a short overview of computational models in cartilage and bone tissue engineering with a focus on how mechanical cues can regulate...