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Hemodynamic Cardiovascular Indices to Predict the Response to Angiotensin-II in Septic Shock
Septic shock is known to severely impair cardiovascular function, leading to altered pulse wave transmission and blood pressure (BP) control. Current...
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Unraveling the complexity of vascular tone regulation: a multiscale computational approach to integrating chemo-mechano-biological pathways with cardiovascular biomechanics
Vascular tone regulation is a crucial aspect of cardiovascular physiology, with significant implications for overall cardiovascular health. However,...
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Models for Closed-Loop Cardiac Control Using Vagal Nerve Stimulation
Vagal nerve stimulation has shown beneficial effects in treating cardiovascular diseases. However, the lack of clinical efficacy, as well as...
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A multiscale framework for defining homeostasis in distal vascular trees: applications to the pulmonary circulation
Pulmonary arteries constitute a low-pressure network of vessels, often characterized as a bifurcating tree with heterogeneous vessel mechanics....
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Computational simulation-derived hemodynamic and biomechanical properties of the pulmonary arterial tree early in the course of ventricular septal defects
Untreated ventricular septal defects (VSDs) can lead to pulmonary arterial hypertension (PAH) characterized by elevated pulmonary artery (PA)...
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Structural design and mechanical performance of composite vascular grafts
This study reviews the state of the art in structural design and the corresponding mechanical behaviours of composite vascular grafts. We critically...
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A biochemomechanical model of collagen turnover in arterial adaptations to hemodynamic loading
The production, removal, and remodeling of fibrillar collagen is fundamental to mechanical homeostasis in arteries, including dynamic morphological...
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Biomaterial Interface in Cardiac Cell and Tissue Engineering
Cardiovascular diseases continue to be the leading cause of death while available clinical interventions have limited contributions to heart repair...
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Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion
Accurate modeling of blood dynamics in the coronary microcirculation is a crucial step toward the clinical application of in silico methods for the...
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A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics
Hemodynamic loading is known to contribute to the development and progression of pulmonary arterial hypertension (PAH). This loading drives changes...
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A homogenized constrained mixture model of cardiac growth and remodeling: analyzing mechanobiological stability and reversal
Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal,...
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Models for Closed-Loop Cardiac Control Using Vagal Nerve Stimulation
Vagal nerve stimulation has shown beneficial effects in treating cardiovascular diseases. However, the lack of clinical efficacy, as well as...
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Computational Studies on the Hemodynamics of Patient-Specific Human Carotid Artery
Atherosclerosis is a cardiovascular disease that affects large and medium-sized arteries and is characterised by intricate interactions between the...
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A parametric study of the effect of 3D plaque shape on local hemodynamics and implications for plaque instability
The vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus...
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Development of a Computational Simulator of the Physiological Control of Ventricular Assist Devices (VADs)
Congestive Heart Failure (CHF) is a significant global health issue and considered the most debilitating form of Heart Failure with the heart unable...
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Mesenchymal Stem Cells Derived from Human Amniotic Membrane Increase VEGF and Extenuate Fibrosis in Heart Failure Rats
Heart failure (HF) is a leading cause of death that has remained incurable. Recently, stem cell therapy has emerged as a promising tool in cardiac...
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Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms
The biomechanical and hemodynamic effects of atherosclerosis on the initiation of intracranial aneurysms (IA) are not yet clearly discovered. Also,...
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Non-invasive parameters of autonomic function using beat-to-beat cardiovascular variations and arterial stiffness in hypertensive individuals: a systematic review
PurposeNon-invasive, beat-to-beat variations in physiological indices provide an opportunity for more accessible assessment of autonomic dysfunction....
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In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model
Methods of tissue engineering continue to advance, and multiple clinical trials are underway evaluating tissue engineered vascular grafts (TEVGs)....
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Innovative Technologies for Intrauterine Monitoring of Predictive Markers of Vascular and Neurological Well-Being
After Barker’s hypothesis, an increasing number of subsequent epidemiological studies confirmed the link among low birth weight (LBW), rapid weight...