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Combination of stem cell-derived secretome from human exfoliated deciduous teeth with Yemeni Sidr honey on cell viability and migration: an in vitro study
IntroductionBone diseases have a profound global impact, especially when the body’s innate regenerative capacity falls short in the face of extensive...
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Photobiostimulation conjugated with stem cells or their secretome for temporomandibular joint arthritis in a rat model
BackgroundTemporomandibular joint (TMJ) arthritis is a debilitating, challenging condition and different methods have been implicated for its...
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Translating proteome and transcriptome dynamics of periodontal ligament stem cell-derived secretome/conditioned medium in an in vitro model of periodontitis
BackgroundPeriodontal ligament stem cells (PDLSCs) have been proposed as therapeutic candidates in periodontal diseases and periodontium defects....
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Bioprinting salivary gland models and their regenerative applications
ObjectiveSalivary gland (SG) hypofunction is a common clinical condition arising from radiotherapy to suppress head and neck cancers. The radiation...
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Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells
The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin, coupled with their ready...
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Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune response of oral epithelial cells on titanium surfaces
ObjectivesWhile the significant roles of outer membrane vesicles (OMVs) from individual oral bacterial species in bacterial-host interactions are...
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Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral...
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Inflammatory and bone remodelling related biomarkers following periodontal transplantation of the tissue engineered biocomplex
ObjectivesTo assess gingival crevicular fluid (GCF) levels of inflammatory and bone remodelling related biomarkers following transplantation of a...
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Which substances loaded onto collagen scaffolds influence oral tissue regeneration?—an overview of the last 15 years
BackgroundCollagen scaffolds are widely used for guided bone or tissue regeneration. Aiming to enhance their regenerative properties, studies have...
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Release kinetics and mitogenic capacity of collagen barrier membranes supplemented with secretome of activated platelets - the in vitro response of fibroblasts of the periodontal ligament and the gingiva
BackgroundPlatelet preparations can stimulate the healing process and have mitogenic properties. We hypothesized that collagen barrier membranes...
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Considerations for Designing Next-Generation Composite Dental Materials
Tooth-colored dental restorations, especially the ones produced chairside, have relatively short durability, leading to additional tooth loss and...
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Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis
Immunoglobulin G4-related sialadenitis (IgG4-RS) is an immune-mediated fibro-inflammatory disease and the pathogenesis is still not fully understood....
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Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate–based cements by RNA sequencing
ObjectivesTricalcium silicate (TCS)–based biomaterials induce differentiation of human dental pulp cells (hDPCs) into odontoblasts/osteoblasts, which...
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A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells
Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach...
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Immune expression profile identification in a group of proliferative verrucous leukoplakia patients: a pre-cancer niche for oral squamous cell carcinoma development
ObjectivesTo explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and...
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Photobiomodulation effect on angiogenic proteins produced and released by dental pulp cells
ObjectiveTo verify the photobiomodulation effect on angiogenic proteins produced and released by dental human pulpal fibroblasts (HPFs).
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Current and Future Views on Pulpal Angiogenesis
The centre of the tooth harbours the dental pulp, a soft connective tissue which plays a pivotal role in the homeostasis of tooth vitality and...
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Protein- and Cell-Based Therapies for Periodontal Regeneration
To fully regenerate the periodontal tissues remains a challenge in our daily practice. Periodontal regeneration is a complex process involving a...
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Modification of collagen-based sponges can induce an upshift of the early inflammatory response and a chronic inflammatory reaction led by M1 macrophages: an in vivo study
BackgroundThe present study evaluated the cellular tissue reaction of two equine-derived collagen hemostatic sponges (E-CHS), which differed in...
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Current Understanding and Future Applications in Dentine-Pulp Complex Inflammation and Repair
Infecting oral microorganisms, which penetrate through the tooth’s enamel and dentine, are responsible for dental caries. During the caries process,...