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MicroRNA expression in JAG1/Notch-activated periodontal ligament stem cells
ObjectivesThe study explored the expression profile of miRNAs in Notch-activated periodontal ligament stem cells (PDLSCs) and examined their...
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Translating proteome and transcriptome dynamics of periodontal ligament stem cell-derived secretome/conditioned medium in an in vitro model of periodontitis
BackgroundPeriodontal ligament stem cells (PDLSCs) have been proposed as therapeutic candidates in periodontal diseases and periodontium defects....
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Effect of an low-energy Nd: YAG laser on periodontal ligament stem cell homing through the SDF-1/CXCR4 signaling pathway
BackgroundThe key to the success of endogenous regeneration is to improve the homing rate of stem cells, and low-energy laser is an effective...
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Exploring the Role of Wnt Ligands in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
ObjectivesThis study aimed to investigate the functions of 19 types of Wnt ligands during the process of osteogenic differentiation in human...
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Periodontal ligament stem cell-derived exosome-loaded Emodin mediated antimicrobial photodynamic therapy against cariogenic bacteria
BackgroundThis study was conducted to investigate the efficiency of periodontal ligament (PDL) stem cell-derived exosome-loaded Emodin (Emo@PDL-Exo)...
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Promotion effect of apical tooth germ cell-conditioned medium on osteoblastic differentiation of periodontal ligament stem cells through regulating miR-146a-5p
BackgroundMicroRNAs (miRNAs) play an important role in gene regulation that controls stem cells differentiation. Periodontal ligament stem cells...
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Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression
BackgroundButyrate is a major subgingival microbial metabolite that is closely related to periodontal disease. It affects the proliferation and...
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Comparative biological properties of resin-free and resin-based calcium silicate-based endodontic repair materials on human periodontal ligament stem cells
ObjectivesTo investigate the effect of three different calcium silicate-based materials (CSBM) on the biological behavior of human periodontal...
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The mechanism of lncRNA MALAT1 targeting the miR-124-3p/IGF2BP1 axis to regulate osteogenic differentiation of periodontal ligament stem cells
ObjectivesThis study aimed to investigate the regulatory roles of lncRNA MALAT1, miR-124-3p, and IGF2BP1 in osteogenic differentiation of periodontal...
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Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells
ObjectiveAdenosine triphosphate (ATP) is an essential nucleotide that is normally present in both intracellular and extracellular compartments....
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Stem cell-based therapy in periodontal regeneration: a systematic review and meta-analysis of clinical studies
BackgroundPeriodontitis is a common and chronic inflammatory disease characterized by irreversible destruction of the tooth surrounding tissues,...
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TAZ reverses the inhibitory effects of LPS on the osteogenic differentiation of human periodontal ligament stem cells through the NF-κB signaling pathway
BackgroundHuman periodontal ligament stem cells (hPDLSCs) are important candidate seed cells for periodontal tissue engineering, but the presence of...
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NAT10 promotes osteogenic differentiation of periodontal ligament stem cells by regulating VEGFA-mediated PI3K/AKT signaling pathway through ac4C modification
Periodontal tissue regeneration engineering based on human periodontal ligament stem cells (hPDLSCs) provides a broad prospect for the treatment of...
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Comprehensive analysis of M2 macrophage-derived exosomes facilitating osteogenic differentiation of human periodontal ligament stem cells
BackgroundThe role of periodontal ligament stem cells (PDLSCs) and macrophage polarization in periodontal tissue regeneration and bone remodeling...
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Alteration of extracellular matrix proteins in atrophic periodontal ligament of hypofunctional rat molars
ObjectivesThe aim of this study was to investigate the effect of mechanical force on possible dynamic changes of the matrix proteins deposition in...
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What is the impact of e-cigarettes on periodontal stem cells as revealed by transcriptomic analyses?
DesignThe research used an in vitro cell exposure model and multi-omics integration of transcriptome and epigenome profiling to compare the molecular...
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The molecular weight of hyaluronic acid influences metabolic activity and osteogenic differentiation of periodontal ligament cells
ObjectiveWhile HA is present naturally in periodontal tissues, its molecular weight can vary widely in vivo. The objective of this study was to...
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Gene expression profiling on effect of aspirin on osteogenic differentiation of periodontal ligament stem cells
Periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative...
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Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling
BackgroundThe aim of this study was to investigate the protective effect and mechanism of oridonin in an in vitro lipopolysaccharide (LPS)-induced...
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Stem cell microencapsulation maintains stemness in inflammatory microenvironment
Maintaining the stemness of the transplanted stem cell spheroids in an inflammatory microenvironment is challenging but important in regenerative...
