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COL1A1, mediated by m6A methylation of METTL3, facilitates oral squamous cell carcinoma cell growth and metastasis
Collagen type I alpha1 (COL1A1) has been found to be abnormal expressed in oral squamous cell carcinoma (OSCC) tissues, but its role and mechanism in...
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Identifying factors related to delayed neck metastasis after surgical treatment in patients with oral squamous cell carcinoma
BackgroundGeneral treatment of oral squamous cell carcinoma (OSCC) is surgical treatment with or without neck dissection. Although the incidence of...
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Occult metastasis is no burden factor in oral squamous cell carcinoma patients when adhering to a standardized approach in neck dissection
ObjectivesManagement of the neck in patients with oral squamous cell carcinoma (OSCC) is pivotal to oncologic control and survival. However, there is...
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Increased levels of PD1 and glycolysis in CD4+ T cells are positively associated with lymph node metastasis in OSCC
BackgroundCervical lymph node metastasis is one of the poorest prognostic factors in oral squamous cell carcinoma (OSCC). Activated immune cells...
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Volume-based 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters correlate with delayed neck metastasis in clinical early-stage oral squamous cell carcinoma
ObjectiveThere is no known preoperative marker that can effectively predict the risk of delayed neck metastasis (DNM), which is an important factor...
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The role of unconventional lymph node metastasis in neck recurrence among patients with tongue cancer
ObjectivesStatistics on the rate of unconventional lymph node metastases (ULNM) at the time of one-stage radical surgery in tongue cancer patients....
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A deep learning and radiomics fusion model based on contrast-enhanced computer tomography improves preoperative identification of cervical lymph node metastasis of oral squamous cell carcinoma
ObjectivesIn this study, we constructed and validated models based on deep learning and radiomics to facilitate preoperative diagnosis of cervical...
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High diagnostic accuracy for lymph node metastasis of oral squamous cell carcinoma using PET/CT with a silicon photomultiplier
ObjectiveThe higher sensitivity of the new-generation positron emission tomography/computed tomography (PET/CT) with silicon photomultiplier (SiPM)...
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Laterality on FDG-PET/CT in clinically node-negative early-stage oral squamous cell carcinoma: a retrospective analysis of patients with late neck metastasis
This study aimed to assess the role of preoperative 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for...
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Prognostic factors for lymph node metastasis from upper gingival carcinomas
ObjectivesThis study sought to identify tumor characteristics that associate with regional lymph node metastases in squamous cell carcinomas...
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Radiological spectrum of metastasis to the oral and maxillofacial region
ObjectiveOral and maxillofacial metastasis may be the first indication of an undiscovered malignancy in a significant number of cases. Therefore, the...
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P-Cadherin and WNT5A expression in assessment of lymph node metastasis in oral squamous cell carcinoma
BackgroundOral cancer progression is a multi-step process in which adhesion molecules play a pivotal role in the development of recurrent, invasive,...
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FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence,...
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Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma
BackgroundThe aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the...
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Radiomics analysis of [18F]-fluoro-2-deoxyglucose positron emission tomography for the prediction of cervical lymph node metastasis in tongue squamous cell carcinoma
ObjectivesThis study aimed to create a predictive model for cervical lymph node metastasis (CLNM) in patients with tongue squamous cell carcinoma...
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PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling
Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary; however,...
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Medial clavicle fracture with bone destruction after radical neck dissection combined with postoperative chemotherapy for secondary cervical lymph node metastasis of tongue cancer: a case report
BackgroundClavicle fractures (CF) after radical neck dissection (RND) for oral cancer are rare but are thought to occur as a result of myotonia and...
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Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer
Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic, recurrence and metastasis of oral cancer occur after...
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The 8th AJCC classification is inferior to a new neck stage based on intraparotid lymph node in parotid gland cancer
BackgroundLymph node (LN) status is an important prognostic factor for parotid gland cancer (PGC). This study aimed to analyze the impact of...