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Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment
BackgroundEpiregulin (EREG) is an important component of EGF and was demonstrated to promote the osteo/dentinogenic differentiation of stem cells...
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miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition
Human dental pulp stem cells (DPSCs) have emerged as an important source of stem cells in the tissue engineering, and hypoxia will change various...
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Evaluation of a hyaluronic acid hydrogel (Restylane Lyft) as a scaffold for dental pulp regeneration in a regenerative endodontic organotype model
Scaffolds are crucial elements for dental pulp regeneration. Most of the currently used scaffolds in regenerative endodontic procedures (REPs) are...
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The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells
BackgroundHuman dental pulp stem cells (hDPSCs) may be the best choice for self-repair and regeneration of teeth and maxillofacial bone tissue due to...
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The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation
Therapeutic dentin regeneration remains difficult to achieve, and a majority of the attention has been given to anabolic strategies to promote...
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WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla
BackgroundOdontogenic mesenchymal stem cells (MSCs) isolated from tooth tissues are a reliable resource that can be utilized for dental tissue...
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Effect of diode low level laser and red light emitting diode irradiation on cell proliferation and osteogenic/odontogenic differentiation of stem cells from the apical papilla
BackgroundThis experimental study aimed to assess the effect of irradiation of red light-emitting diode (LED) and Diode low-level laser (LLL) on...
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Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation
BackgroundDuring the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the...
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Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny
Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig’s epithelial root...
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Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumours
BackgroundEctopic odontogenic tumours are rare and difficult to diagnose. Consequently, they are occasionally misdiagnosed as other tumours and...
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Comparative evaluation of the effect of cold ceramic and MTA-Angelus on cell viability, attachment and differentiation of dental pulp stem cells and periodontal ligament fibroblasts: an in vitro study
BackgroundBiocompatibility and induction of mineralized tissue formation are the properties expected from a material used in vital pulp therapy and...
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Biological Basis for Repair and Regeneration in Modern Endodontics and New Treatment Considerations
Achieving long-lasting and complete pulp regeneration in young permanent teeth with deep caries or severe trauma remains a significant clinical...
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Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression
BackgroundButyrate is a major subgingival microbial metabolite that is closely related to periodontal disease. It affects the proliferation and...
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Challenging pitfalls in frozen section pathology: a case of mandible ghost cell odontogenic carcinoma and the literature review
BackgroundGhost cell odontogenic carcinoma (GCOC) is a rare malignancy characterized by the presence of ghost cells, preferably in the maxilla. Only...
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Effects of histone acetyltransferase (HAT) and histone deacetylase (HDAC) inhibitors on proliferative, differentiative, and regenerative functions of Toll-like receptor 2 (TLR-2)-stimulated human dental pulp cells (hDPCs)
ObjectivesThis in vitro study aimed to modify TLR-2-mediated effects on the paracrine, proliferative, and differentiation potentials of human dental...
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The effect of three additives on properties of mineral trioxide aggregate cements: a systematic review and meta-analysis of in vitro studies
BackgroundSeveral efforts have been made to improve mechanical and biological properties of calcium silicate-based cements through changes in...
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MicroRNA and their implications in dental pulp inflammation: current trends and future perspectives
MicroRNAs (miRNAs) are short, 19–23 nucleotide non-coding RNA molecules that regulate gene expression by silencing or degrading the target mRNA gene....
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Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation
Once pulp necrosis or apical periodontitis occurs on immature teeth, the weak root and open root apex are challenging to clinicians. Berberine (BBR)...
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The potential use of ascorbic acid to recover the cellular senescence of lipopolysaccharide-induced human apical papilla cells: an
in vitro studyObjectivesTo examine the effect of lipopolysaccharide (LPS) on cellular senescence induction of human apical papilla cells (hAPCs) and evaluate the...
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Biodegradation of an injectable treated dentin matrix hydrogel as a novel pulp cap** agent for dentin regeneration
BackgroundA novel injectable mixture termed treated dentin matrix hydrogel (TDMH) has been introduced for restoring dentin defect in DPC. However, no...
