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How to Conduct a Clinical Trial: Overview
This chapter lays the groundwork for understanding the science of clinical trials. It is a primer on conceptualizing and operationalizing a clinical...
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Bridging the gap between omics research and dental practice
AimThe burgeoning field of omics research has witnessed exponential growth in both medicine and dentistry. However, despite more than a decade of...
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Clinical Features: Oral Submucous Fibrosis
Oral submucous fibrosis (OSF) develops insidiously, and as the early signs and symptoms are rather non-specific, the clinical presentation can be...
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Heterogeneity of outcomes in randomized controlled trials on implant prosthodontic therapy is hindering comparative effectiveness research: meta-research study
BackgroundConsistency in outcomes across clinical trials allows for comparing and combining results from different studies. A core outcome set (COS),...
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Research efficacy of gaseous ozone therapy as an adjuvant to periodontal treatment on oxidative stress mediators in patients with type 2 diabetes: a randomized clinical trial
BackgroundChronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between...
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Validation of an implant stability measurement device using the percussion response: a clinical research study
BackgroundSeveral devices have been developed to measure implant-bone stability as an indicator of successful implant treatment; these include...
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Pulp Response to Clinical Procedures and Dental Materials
This chapter aims to provide readers with reliable, evidence-based data obtained from laboratory studies and clinical trials performed in the last...
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Clinical Challenges and Longevity of Bulk-Fill Materials
There is limited information from clinical trials, especially randomized clinical trials (RCTs), on clinical performance of bulk-fill composites....
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Clinical and microbiological efficacy of intra-pocket application of diode laser in grade C periodontitis: a randomized controlled clinical trial
BackgroundPeriodontitis is a microbially induced disease destroying structures anchoring teeth to jaw bones. Although metronidazole in combination...
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Photobiomodulation Therapy Within Clinical Dentistry: Theoretical and Applied Concepts
Photobiomodulation therapy (PBMT), formerly known as low-level laser therapy, is the targeted application of light for therapeutic purposes at a low...
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The Role of Randomized Controlled Trials in Clinical Dentistry and Future Directions
In clinical practice, one never knows if the particular treatment chosen was the best for the patient under their particular circumstances. There are...
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Pediatric Considerations in Clinical Pharmacology
Safe and effective administration of drugs to children requires an understanding of age-related differences between children and adults. Specific age...
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Clinical and radiographic outcomes of a two-piece ceramic implant: one year results from a prospective clinical trial
ObjectiveTo describe the clinical and radiographic performance and survival rate of a new two-piece ceramic implant system after at least 12 months...
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Dental and periodontal dimensions stability after esthetic clinical crown lengthening surgery: a 12‐month clinical study
ObjectivesTo evaluate the stability of periodontal tissues 3 (T 3 ), 6 (T 6 ), and 12 (T 12 ) months after esthetic crown lengthening (ACL) and the...
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Implant stability and clinical outcome between implant placement using internal sinus floor elevation with alloplastic bone material grafting and without grafting: A 1-year randomized clinical trial
ObjectiveTo compare implant stability and clinical outcome in implant placement between osteotome sinus floor elevation (OSFE) with biphasic calcium...
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Comparing traditional and comprehensive clinical training methods in dental education: a study of students' self-confidence and clinical performance
Aim To compare students' self-confidence levels and clinical performance scores between traditional and comprehensive clinical training methods in...
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Clinical evaluation of different alveolar ridge preservation techniques after tooth extraction: a randomized clinical trial
ObjectiveThe aim of the present randomized controlled trial (RCT) was to evaluate the efficacy of different alveolar ridge preservation (ARP)...
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Two-year clinical performance of dual- and light-cure bulk-fill resin composites in Class ӀӀ restorations: a randomized clinical trial
ObjectiveThis study aimed to compare the clinical performance of dual- and light-cure bulk-fill resin composites (BFRCs) in Class ӀӀ restorations...
