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Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma
With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of...
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Familial oligodontia and regional odontodysplasia associated with a PAX9 initiation codon mutation
ObjectiveTooth agenesis is one of the most common craniofacial developmental anomalies. In hypodontia, one to five teeth are missing, whereas...
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A survey of prescribing practices by general dentists in Australia
BackgroundNumerous studies of dental antibiotic prescribing show that overprescribing is a worldwide occurrence. The aim of this study was to assess...
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Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate
ObjectiveOrofacial development is a complex process subjected to failure impairing. Indeed, the cleft of the lip and/or of the palate is among the...
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Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
BackgroundPeriodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox...
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Non-infectious Diseases of the Oral Mucosa: The Importance of Immune Functions
Introduction: The non-microbial diseases of the oral mucosa constitute a heterogenous group of disorders from rare life-threatening autoimmune...
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Pilot GWAS of caries in African-Americans shows genetic heterogeneity
BackgroundDental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable,...
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Genetics and Molecular Mechanisms in Oral Cancer Progression
Exposure to tobacco in smoke or chewable form, in isolation or in association with other risk factors (i.e., alcohol or areca nut), disturbs the...
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Transmission patterns of Streptococcus mutans demonstrated by a combined rep-PCR and MLST approach
ObjectiveClinical ty** methods of the oral pathogen Streptococcus mutans with molecular analysis can be very specific, but expensive. Repetitive...
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Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer
ObjectivesOral cancer is the most common head and neck malignancy, and it is associated with a high recurrence rate and lymph node metastasis...
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Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with oral cancer
PurposeOral squamous cell carcinoma (OSCC)—a subset of head and neck cancer is the sixth most common cancer worldwide and leading disease in India....
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Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions
ObjectivesGenetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation....
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Laboratory Medicine and Diagnostic Pathology
Laboratory tests play an important role in clinical diagnosis, and the results often direct patient management. Tests should be requested...
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Oral Vesicular and Bullous Lesions
Vesiculobullous disorders involving the oral cavity may also affect the skin and other mucous membranes. They may thus reflect the oral...
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Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
BackgroundThere are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 ( TP53 )...
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Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility
BackgroundOral lichen planus (OLP) is a premalignant mucocutaneous disease in which genetic factors and immune responses play a major role. Cytokines...
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Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular...
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Novel caries loci in children and adults implicated by genome-wide analysis of families
BackgroundDental caries is a common chronic disease among children and adults alike, posing a substantial health burden. Caries is affected by...
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Genetic Biomarkers of Orofacial Pain Disorders
Despite major advances in basic and translational research, pain medicine still offers no cure for persistent orofacial pain disorders, nor effective...
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Oral and Maxillofacial Fungal Infections
Human fungal infections caused by opportunistic fungi generally do not cause lesions in healthy individuals but rather in patients who are...