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Splicing mutations in AMELX and ENAM cause amelogenesis imperfecta
BackgroundAmelogenesis imperfecta (AI) is a developmental enamel defect affecting the structure of enamel, esthetic appearance, and the tooth...
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Diagnosis
There are two clinical OLP subtypes: the white forms of OLP (papular, reticular, annular, and plaque) should be considered as quiescent variants of...
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Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis
BackgroundAlthough obstructive sleep apnea (OSA) and periodontitis are associated, whether this association is causative is uncertain.
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Ligneous periodontitis exacerbated by Behçet’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C > T: a case report
BackgroundPlasminogen serves as the precursor to plasmin, an essential element in the fibrinolytic process, and is synthesized primarily in the...
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Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans
BackgroundExternal apical root resorption (EARR) is a common undesirable outcome of orthodontic treatment, this study aimed to identify genetic...
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Metastasising ameloblastoma or ameloblastic carcinoma? A case report with mutation analyses
BackgroundAmeloblastic carcinoma and metastasising ameloblastoma are rare epithelial odontogenic tumours with aggressive features. Distinguishing...
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Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case–control study
ObjectivesDental caries is a widespread multifactorial disease, caused by the demineralization of hard dental tissues. Susceptibility to dental...
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No genetic causal associations between periodontitis and brain atrophy or cognitive impairment: evidence from a comprehensive bidirectional Mendelian randomization study
BackgroundObservational studies have explored the relationships of periodontitis with brain atrophy and cognitive impairment, but these findings are...
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Disrupted tenogenesis in masseter as a potential cause of micrognathia
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the...
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The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study
BackgroundDental caries is one of the most prevalent chronic diseases worldwide among children. The rs35874116 single nucleotide polymorphism (SNP)...
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Periodontitis and pulmonary function: a Mendelian randomization study
ObjectivesObservational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding...
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Dietary and metabolic effects on the oral status of patients with phenylketonuria: a nation-based cross-sectional study
ObjectivesThe aim of this study was to compare the prevalence of oral diseases (caries, periodontal disease, enamel defects) between patients with...
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Meta-analyses of the relationship between five CXCL8 gene polymorphisms and overall cancer risk, and a case-control study of oral cancer
BackgroundC-X-C motif chemokine ligand (CXCL8), also known as interleukin-8, is a prototypical CXC family chemokine bearing a glutamic...
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Analyses of oligodontia phenotypes and genetic etiologies
Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis. Many genes have been implicated in...
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Craniofacial, dental, and molecular features of Pyle disease in a South African child
IntroductionPyle Disease (PD), or familial metaphyseal dysplasia [OMIM 265900], is a rare autosomal recessive condition leading to widened metaphyses...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
BackgroundChronic periodontitis (CP), defines as destruction of the supporting tissues of the teeth and resorption of the alveolar bone. It is...
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Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human
BackgroundPeriodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its...
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Welcome to the new genomics: an introduction to the NHS Genomic Medicine Service for oral healthcare professionals
Genomic medicine is on the threshold of a significant advance in the United Kingdom (UK) with the introduction of a National Health Service (NHS)...
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Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population
BackgroundVitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the...
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Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study
ObjectivesThis study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the...
