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Effect of graphene oxide/ poly-L-lactic acid composite scaffold on the biological properties of human dental pulp stem cells
BackgroundTissue engineering has attracted recent attention as a promising bone repair and reconstruction approach. Dental pulp stem cells (DPSCs)...
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Inhibition of ZDHHC16 promoted osteogenic differentiation and reduced ferroptosis of dental pulp stem cells by CREB
BackgroundThe repair of bone defects caused by periodontal diseases is a difficult challenge in clinical treatment. Dental pulp stem cells (DPSCs)...
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The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells
BackgroundHuman dental pulp stem cells (hDPSCs) may be the best choice for self-repair and regeneration of teeth and maxillofacial bone tissue due to...
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Effect of PCL/nHAEA nanocomposite to osteo/odontogenic differentiation of dental pulp stem cells
PurposeThe green synthesis of nanoparticles has recently opened up a new route in material production. The aim of this study was to evaluate the...
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METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability
BackgroundThe dentinogenesis differentiation of dental pulp stem cells (DPSCs) is controlled by the spatio-temporal expression of differentiation...
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Comparative chemical properties, bioactivity, and cytotoxicity of resin-modified calcium silicate–based pulp cap** materials on human dental pulp stem cells
ObjectivesThis study investigated the cytotoxicity, the residual monomer release, degree of conversion (DC), calcium ion (Ca 2+ ) release, and crystal...
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Elucidating Tooth Development and Pulp Biology by Single-Cell Sequencing Technology
Single-cell RNA sequencing (scRNA-seq) is a powerful technique that enables scientists to interrogate the expression level of every gene in...
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Evaluation of oxidative stress cycle in healthy and inflamed dental pulp tissue: a laboratory investigation
ObjectivesThe purpose of this study was to investigate the oxidative stress cycle consisting of reactive oxygen molecules (ROS), glutathione (GSH)...
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MicroRNA and their implications in dental pulp inflammation: current trends and future perspectives
MicroRNAs (miRNAs) are short, 19–23 nucleotide non-coding RNA molecules that regulate gene expression by silencing or degrading the target mRNA gene....
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Evaluation of dental pulp stem cells behavior after odontogenic differentiation induction by three different bioactive materials on two different scaffolds
BackgroundTo study the odontogenic potential of dental pulp stem cells (DPSCs) after induction with three different bioactive materials: activa...
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The protective role of curcumin in human dental pulp stem cells stimulated by lipopolysaccharide via inhibiting NF-κB p65 phosphorylation to suppress NLRP3 inflammasome activation
ObjectivesThis study aims to investigate the anti-inflammatory effect of curcumin and underlying mechanisms regarding the modulation of the nod-like...
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Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation
BackgroundDuring the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the...
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Blue light photobiomodulation of dental pulp cells
PurposeBlue light has been reported to enhance the differentiation and mineralisation potential of mesenchymal stem cells. No studies have...
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Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways
Sphingosine-1-phosphate (S1P) is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are...
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Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration
Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition supply. The approach based on endogenous stem cells is a...
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Betaine promotes osteogenic differentiation in immortalized human dental pulp-derived cells
ObjectivesThis study aimed to evaluate the effect of betaine (BET) on immortalized human dental pulp stem cell (ihDP) osteogenic differentiation.
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The growth factor multimodality on treating human dental mesenchymal stem cells: a systematic review
BackgroundEnsuring the quantity, quality, and efficacy of human dental mesenchymal stem cells (MSCs) has become an urgent problem as their...
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Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation
X-linked hypophosphatemia (XLH) represents the most common form of familial hypophosphatemia. Although significant advances have been made in the...
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Leukotriene B4 loaded in microspheres regulate the expression of genes related to odontoblastic differentiation and biomineralization by dental pulp stem cells
BackgroundLeukotriene B 4 (LTB 4 ) is a potent lipid mediator that stimulate the immune response. Because dental pulp inflammation and dentin repair...
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Effects of phytosomal curcumin treatment on modulation of immunomodulatory and pulp regeneration genes in dental pulp mesenchymal stem cells
Dental pulp stem cells (DPSCs) are a new population of mesenchymal stem cells (MSCs) located in the oral cavity with potential capacities for tissue...
