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Droplet microarray platforms for high-throughput drug screening
AbstractHigh-throughput screening platforms are fundamental for the rapid and efficient processing of large amounts of experimental data....
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Probing the chemical ‘reactome’ with high-throughput experimentation data
High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity...
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High-throughput process development from gene cloning to protein production
In the post-genomic era, the demand for faster and more efficient protein production has increased, both in public laboratories and industry. In...
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Ultrahigh-throughput screening-assisted in vivo directed evolution for enzyme engineering
BackgroundClassical directed evolution is a powerful approach for engineering biomolecules with improved or novel functions. However, it...
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Optical-Switch Raman Spectroscopy for High Throughput Screening
Although surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique with unbeaten sensitivity, the capabilities of SERS have been...
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High-throughput platforms for microextraction techniques
The proposal of high-throughput platforms in microextraction-based approaches is important to offer sustainable and efficient tools in analytical...
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High-throughput reprogramming of an NRPS condensation domain
Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is...
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Recent Progress in High-Throughput Enzymatic DNA Synthesis for Data Storage
DNA has emerged as an attractive medium for storing large amounts of data due to its high information density, long-term stability, and low energy...
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High-throughput and proteome-wide discovery of endogenous biomolecular condensates
Phase separation inside mammalian cells regulates the formation of the biomolecular condensates that are related to gene expression, signalling,...
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Magnetic Microtweezers for High-Throughput Bioseparation in Sub-Nanoliter Droplets
Multiomics studies at single-cell level require small volume manipulation, high throughput analysis, and multiplexed detection, characteristics that...
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High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction
Rapid phase elucidation of polycrystalline materials is essential for develo** new materials of chemical, pharmaceutical and industrial interest....
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A high-throughput platform for efficient exploration of functional polypeptide chemical space
Rapid and in-depth exploration of the chemical space of high-molecular-weight synthetic polypeptides via ring-opening polymerization of N -carboxyanhyd...
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High Throughput Screening in Drug Discovery: Problems and Solutions
AbstractWorld-wide introduction of high throughput screening (HTS) methods in drug discovery research did not result in the increased number of novel...
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Microfluidics-driven high-throughput phenoty** and screening in synthetic biology: from single cells to cell-free systems
The interdisciplinary nature of synthetic biology merges engineering principles with biology and provides innovative solutions for issues in the...
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Functional Peptides from One-bead One-compound High-throughput Screening Technique
C ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC)...
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Generation of macro- and microplastic databases by high-throughput FTIR analysis with microplate readers
FTIR spectral identification is today’s gold standard analytical procedure for plastic pollution material characterization. High-throughput FTIR...
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Review of the technological advances for the preparation of colloidal dispersions at high production throughput using microporous membrane systems
The membrane emulsification (ME) method is a highly promising technology that utilizes synthetic microporous membranes to produce high-quality,...
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High-Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases
Covalent inhibition has gained increasing interest in targeting the undruggable protein tyrosine phosphatases (PTPs). However, a systematic method...
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RNA Structure Determination by High-Throughput Structural Analysis
RNA functions are closely linked with their structures. Therefore, elucidating the secondary structure of RNAs provides crucial information regarding...
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‘Small volume—big problem’: culturing Yarrowia lipolytica in high-throughput micro-formats
With the current progress in the ‘design’ and ‘build’ stages of the ‘design-build-test-learn’ cycle, many synthetic biology projects become...
