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Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration
BackgroundSustained release of bioactive BMP2 (bone morphogenetic protein-2) is important for bone regeneration, while the intrinsic short half-life...
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Engineering a triple-functional magnetic gel driving mutually-synergistic mild hyperthermia-starvation therapy for osteosarcoma treatment and augmented bone regeneration
Malignant bone tumors result in high rates of disability and death and are difficult to treat in terms of killing tumors and repairing bone defects....
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Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis
BackgroundBone regeneration is a complex procedure that involves an interaction between osteogenesis and inflammation. Macrophages in the...
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Hydrogel Biomaterial in Bone Tissue Engineering
The repair of critical-sized bone defect caused by trauma or disease poses a remarkable clinical challenge. Even though conventional methods such as...
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Improvement of Bone Formation in Rats with Calvarial Defects by Modulating the Pore Size of Tricalcium Phosphate Scaffolds
The use of multi-porous scaffolds for bone tissue engineering has been shown to improve osteogenesis. Although the exact mechanisms by which these...
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3D-printed bredigite scaffolds with ordered arrangement structures promote bone regeneration by inducing macrophage polarization in onlay grafts
Bone tissue engineering scaffolds may provide a potential strategy for onlay bone grafts for oral implants. For determining the fate of scaffold...
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Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission
Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges...
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A xonotlite nanofiber bioactive 3D-printed hydrogel scaffold based on osteo-/angiogenesis and osteoimmune microenvironment remodeling accelerates vascularized bone regeneration
BackgroundCoordination between osteo-/angiogenesis and the osteoimmune microenvironment is essential for effective bone repair with biomaterials. As...
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Tissue Engineering Strategies for Craniomaxillofacial Surgery: Current Trends in 3D-Printed Bioactive Ceramic Scaffolds
The advancements in craniomaxillofacial surgical reconstruction have led to improvements in patient-specific treatment care. One of the primary goals...
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Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli
Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact...
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Chitosan: Derivatives, Properties and Applications
Chitosan is biomaterial-derived chitin that is found in abundance in nature. It is one of the main constituents in the shells of crustaceans, insect...
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Polysaccharide-Based Materials for Skeletal Tissue Repair
The ultimate purpose of skeletal tissue engineering is development of convenient engineered construct, which can substitute the damaged areas and...
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Chitosan-based Hydrogels in Drug Delivery
Hydrogels are three-dimensional cross-linked hydrophilic polymers that are able to absorb large quantities of water and swell. They have various...
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Remote coupling of electrical and mechanical cues by diurnal photothermal irradiation synergistically promotes bone regeneration
Recapitulating the natural extracellular physical microenvironment has emerged as a promising method for tissue regeneration, as multiple physical...
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Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of BMSCs through microfilaments and TRPM7
BackgroundLow-intensity pulsed ultrasound (LIPUS) has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy...
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Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration
Guided bone regeneration (GBR) is widely used in treating oral bone defects to exclude the influence of non-osteogenic tissue on the bone healing...
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Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach
Despite the recent advances in the development of bone graft substitutes, treatment of critical size bone defects continues to be a significant...
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3D Printing and Bioprinting of Biomaterials and Bioceramic Scaffolds: Clinical Outcomes and Implications in Bone Tissue Engineering and Maxillofacial Reconstructive Surgery
Three-dimensional (3D) printing is a type of additive manufacturingAdditive Manufacturing that works by the application of material inks layer by...
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Marine-Derived Materials for Hard Tissue Repair and Regeneration
Bone, as a tissue, has a great potential for regeneration; however, in some instances, the injury is too great, or the healing response is inadequate...
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Bioengineering extracellular vesicles: smart nanomaterials for bone regeneration
In the past decade, extracellular vesicles (EVs) have emerged as key regulators of bone development, homeostasis and repair. EV-based therapies have...
