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Anticancer Activity of Coumarin–Pyrazoline Hybrids: A Mini-review
The progress in the field of cytotoxic compounds based on coumarin–pyrazoline hybrids is presented in this literature review. Most of these hybrids...
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Polyplatinaynes Functionalized with Pyrazoline Derivatives
Pyrazoline and pyrazole compounds are important building blocks in the development of photofunctional compounds. Two new solution-processable...
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Synthesis, Biological Evaluation, and Molecular Docking Study of New Pyrazoline-Based Compounds
AbstractThe current study represents the synthesis and characterization of new pyrazoline, pyrazoline-thiazolinone, and pyrazoline-thiazole-based...
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New route to a pyrazoline scaffold featuring original substitutions and its crystal structure
Pyrazolines are among the heterocyclic compounds, a class that exhibit a range of applications in a wide diversity of fields. We report here, a novel...
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Synthesis of Pyrazoline derivatives, condensation of β-dicarbonyl compounds with isoniazid (INH), and their biological evaluation as multitarget anti-Alzheimer’ disease agents
Alzheimer's disease is a complex and progressive form of dementia. Its treatment relies on the behavioral and cognitive symptoms of an individual....
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Ferrocenyl pyrazoline–based gelator for detecting Cu2+ in aqueous solutions
Herein, a novel ferrocenyl pyrazoline – based organic gelator (Z) was synthesised and studied. Adding Z in various solvents could form stable organic...
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Corrosion inhibition behavior of the synthesized pyrazoline-sulfonamide hybrid of mild steel in aqueous solutions: experimental and quantum investigations
This study deals with the preparation and corrosion inhibition investigations of pyrazoline-sulfonamide hybrid, namely...
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Synthesis and Biological Importance of Pyrazole, Pyrazoline, and Indazole as Antibacterial, Antifungal, Antitubercular, Anticancer, and Anti-inflammatory Agents
N-heterocycles have always gained greater attention among the scientific community. Indole, indazole, pyrrole, pyrazole, pyrazoline, pyridine,...
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Asymmetric catalytic 1,3-dipolar cycloaddition of α-diazoesters for synthesis of 1-pyrazoline-based spirochromanones and beyond
A highly enantioselective 1,3-dipolar cycloaddition of α-substituted diazoesters with exocyclic enones was achieved with chiral scandium(III)/ N , N ’-dio...
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A novel pyrazoline-based turn-on fluorescent probe for highly sensitive detection of Al3+ in aqueous solution and its applications
A new fluorescent sensor (E)-3-(1-acetyl-5-styryl-4,5-dihydro-1H -pyrazol-3-yl)-4-hydroxy-6-methyl-2H-pyran-2-one (DRS) for Al 3+ detection was...
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Synthesis, Luminescent Properties, and Antibacterial Activity of New Pyrazoline and Pyrimidine Derivatives of (2E)-1-Biphenyl-3-arylprop-2-en-1-ones
AbstractSubstituted prop-2-en-1-ones were obtained by the condensation reaction of 1-biphenyl-4-yl-ethanone with aromatic aldehydes in the presence...
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Efficient Continuous-Flow Synthesis and Evaluation of Anticancer Activity of Novel Quinoline–Pyrazoline Derivatives
AbstractAn efficient and simple continuous-flow synthetic protocol for novel quinoline-tethered pyrazoline derivatives, which involves condensation...
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A novel pyrazoline-based fluorescence probe armed by pyrene and naphthol system for the selective detection of Cu2+ and its biological application
A photo-induced electron transfer cationic fluorescence probe L 1 based on pyrene-naphthol system was designed to detect the change of Cu 2+ with...
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Synthetic Approaches, Biological Activities, and Structure–Activity Relationship of Pyrazolines and Related Derivatives
It has been established that pyrazolines and their analogs are pharmacologically active scaffolds. The pyrazoline moiety is present in several...
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Anti-AChE and Anti-BuChE Screening of the Fermentation Broth Extracts from Twelve Aspergillus Isolates and GC-MS and Molecular Docking Studies of the Most Active Extracts
Nowadays, the administration of cholinesterase enzyme (acetylcholinesterase: AChE and butyrylcholinesterase: BuChE) inhibitors is very common for the...
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One-pot synthesis, molecular docking, ADMET, and DFT studies of novel pyrazolines as promising SARS-CoV-2 main protease inhibitors
Pyrazoline and its derivatives have numerous prominent pharmacological effects. Focusing on its anti-viral property, we have designed and synthesized...
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Iridium-catalysed synthesis of C,N,N-cyclic azomethine imines enables entry to unexplored nitrogen-rich 3D chemical space
Three-dimensional nitrogen-rich bridged ring systems are of great interest in drug discovery owing to their distinctive physicochemical and...
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Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives
AbstractA small set of structurally different monocarbonyl curcuminoids was prepared and screened for cytotoxic activity. In particular,...
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Influence on the reactivity properties of the substitution by different halogens on the conjugated backbone of the 1,3,5-triaryl-2-pyrazoline skeleton in relation to the increasing alkyloxy chain length: a conceptual density functional theory study
A series of non-substituted 1,3,5-triaryl-2-pyrazolines and pyrazolines substituted with Fluoro (-F), Chloro (-Cl) and Bromo (-Br) groups at the...
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Synthesis and antibacterial evaluation of pyrazolines carrying (benzyloxy)benzaldehyde moiety
A novel series of 1,2,3-triazole-linked pyrazoline analogues were prepared by the reaction of 3-(4-(benzyloxy)phenyl)-1-(1-(arylphenyl)-5-methyl-1 H -1,...
