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Advances in Pharmacokinetics and Pharmacodynamics
This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the...
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7,8-Dihydroxyflavone: Sources, Pharmacokinetics, Bioavailability, and Biological Effects
7,8-dihydroxyflavone (7,8-DHF), a kind of flavonoids, has been reported to have many pharmacological effects such as antioxidant, anti-inflammation,...
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Pharmacokinetics and Pharmacodynamics of Liposomal Nanoparticles
In the past few years, some major advancements in liposome technology have induced the rapid development of new pharmaceutical liposomal...
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Pharmacokinetics of Drug-in-Polymer Matrix-Based Nanoparticulate Drug Delivery System
The application of nanotechnology in drug delivery is gaining much attention from researchers due to their plethora of benefits especially in the...
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Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice
Poly (ADP-ribose) polymerase (PARP) inhibitors that are effective against ovarian and breast cancers with breast cancer susceptibility gene (BRCA)...
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Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications
Magnetic iron oxide nanoparticles (MNPs) have been under intense investigation for at least the last five decades as they show enormous potential for...
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Pharmacokinetics of Long Circulating Inorganic Nanoparticulate Drug Delivery Systems
Inorganic nanoparticles impose huge opportunities to clinicians in field of theranostics. Currently FDA has approved hundreds of inorganic...
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Pharmacokinetics and brain distribution of the therapeutic peptide liraglutide by a novel LC–MS/MS analysis
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog that has been utilized for the treatment of type 2 diabetes mellitus. Liraglutide at a higher...
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An Effective and Sensitive HPLC–MS/MS Method for Determination of Cholic Acid-Coupled Camptothecin Derivative A2 in Rat Pharmacokinetics and Tissue Distribution
Camptothecin bile acid analog (A2) is a camptothecin derivative, which has been verified to possess the high anti-tumor activity. The purpose of this...
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Mycosporine-Like Amino Acids as a Potential Inhibitor of Tyrosinase-Related Protein 1: Computational Screening, Pharmacokinetics, and Molecular Dynamics Simulation
Melanin is the major pigment responsible for the coloring of mammalian skin, hair, and eyes to defend against ultraviolet radiation. However,...
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Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery...
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Differences in Proportion of N-acetyllactosamine and O-acetylated Sialic Acid Have No Significant Effect on the Pharmacokinetics and Biological Activity of Darbepoetin Alfa
Darbepoetin alfa is used to treat anemia in patients with chronic renal failure and is a therapeutic glycoprotein with five N-glycosylation sites and...
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Metallic Gold Nanoparticles: In Vivo Pharmacokinetics and X-Ray Contrast Imaging Studies
Among all metal nanoparticles, gold nanoparticle has emerged as a better drug delivery system, with higher efficiency and less side effects due to...
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A deep neural network: mechanistic hybrid model to predict pharmacokinetics in rat
An important aspect in the development of small molecules as drugs or agrochemicals is their systemic availability after intravenous and oral...
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Nanoparticle Properties Affecting the Drug Release, Absorption, and Pharmacokinetics of Nanoparticulate Drug Delivery Systems
The nanotechnology-based drug delivery enhances the distribution and pharmacokinetic of the drug which in turn ultimately improves the efficacy of...
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Novel hybrid molecules based on triazole-quinoline as potential anticancer agents: screening on MCF-7 cell line, docking studies, and pharmacokinetics evaluation
A novel series of quinoline-based 1,2,3-triazole hybrids were developed by copper-catalyzed 1,3-dipolar cycloaddition reactions of terminal alkyne...
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Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats
Chitooligosaccharides (COSs) have various physiological activities and broad application prospects; however, their pharmacokinetics and tissue...
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Pharmacokinetics and Metabolism of Phytochemicals Having Anti-obesity and Antidiabetic Activity
The pharmacokinetics and metabolic knowledge of natural medicine (phytochemicals and herbal formulations) are highly beneficial for clinical dose...
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Pharmacokinetics of Nanoparticle Systems for Pulmonary Delivery
The introduction of nanotechnology in the pharmaceutical field has incited the attention of researchers to develop nanoparticle-based formulations to...
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Synthesis of N-heterocyclic amides based on (+)-camphoric acid and study of their antiviral activity and pharmacokinetics
Efficient conditions for the synthesis of nitrogen-containing heterocyclic derivatives of (1 R ,3 S )(+)-camphoric acid were selected. A series of...