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Electrochemical detection of the p53 gene using exponential amplification reaction (EXPAR) and CRISPR/Cas12a reactions
An improved electrochemical sensor has been developed for sensitive detection of the p53 gene based on exponential amplification reaction (EXPAR)...
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Target recognition assisted-primer exchange reaction (Ta-PER) for sensitive analysis of p53 gene and its application in analyzing amatoxin-treated samples
Sensitive and reliable detection of the p53 gene plays a significant role in precise cancer targeting and in fundamental research. However,...
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Efficacy of Prunus armenica, Bee venom, and their combinations on p53 and Bcl-2 gene expression in human pancreatic and lung cancer cells
Malignancies are one of the world’s most serious health problems. Pancreatic and lung cancers are two of the most lethal types of cancer, with 5-year...
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USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression
p53 is a tumor suppressor gene activated in response to cellular stressors that inhibits cell cycle progression and induces pro-apoptotic signaling....
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P53: A Key Target in the Development of Osteoarthritis
Osteoarthritis (OA), a chronic degenerative disease characterized mainly by damage to the articular cartilage, is increasingly relevant to the...
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Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop
Apoptosis is a natural physiological process of programmed cell death. It is essential for maintaining the homeostasis of the body and the immune...
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CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination
BackgroundMost patients with ovarian cancer (OC) treated with platinum-based chemotherapy have a dismal prognosis owing to drug resistance. However,...
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Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics
ContextThe mutations in the TP53 gene are the most frequent (50–60% of human cancer) genetic alterations in cancer cells, indicating the critical...
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Gene Nanovector for Genome Therapy
Gene therapy is a potential approach to deal with complicated diseases that are now untreatable. A critical step in the effective gene therapy is the...
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Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles
BackgroundIn a significant proportion of cancers, point mutations of TP53 gene occur within the DNA-binding domain, resulting in an abundance of...
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Silencing E6/E7 Oncoproteins in SiHa Cells Treated with siRNAs and Oroxylum indicum Extracts Induced Apoptosis by Upregulating p53/pRb Pathways
E6 and E7 human papillomavirus (HPV) oncoproteins play a significant role in the malignant transformation of infected cervical cancer cells via...
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Additional Gene Therapeutic Platforms
AdditionalTherapeutic gene technologies are summarized here withOligonucleotide active use of CPPs, which are available to restore the missing gene...
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Nyctanthes arbor-tristis alkaloids activates p53 independent cell death receptor and necroptosis pathways in HepG2 cells
Nyctanthes arbor-tristis is a traditional medicinal plant with potential anti-cancer properties. In this study, crude and alkaloid extracts were...
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Heparanase accelerates the angiogenesis and inhibits the ferroptosis of p53-mutant non-small cell cancers in VEGF-dependent manner
The aim of this study is to explore the effects and specific mechanisms of heparanase on angiogenesis and iron deficiency anemia in TP53 mutant...
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Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy
Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells to achieve the purpose of...
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Materials for Gene Delivery Systems
Gene therapy has garnered a lot of interest in the recent past for the treatment of various life-threatening genetic diseases. Gene therapy involves...
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Design of peptide-based foldamers for inhibiting the Hdm2-p53 interaction using backbone modification: a molecular dynamics study
Protein, as the main cause of cell interactions, can be the key to solving the riddle of cancer and many other diseases. Disorders in protein–protein...
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Integrated virtual screening and molecular dynamics simulation revealed promising drug candidates of p53-MDM2 interaction
In the vast majority of malignancies, the p53 tumor suppressor pathway is compromised. In some cancer cells, high levels of MDM2 polyubiquitinate p53...
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Gene Nanovector for Genome Therapy
Gene therapy is a potential approach to deal with complicated diseases that are now untreatable. A critical step in the effective gene therapy is the...