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Modulating Molecular Interactions in Extruded Pea Protein Isolate
The impact of molecular interactions on the physical properties of extruded pea protein isolate (PPI) is investigated by adding...
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Protein Kinases and their Inhibitors Implications in Modulating Disease Progression
Protein phosphorylation plays an important role in cellular pathways, including cell cycle regulation, metabolism, differentiation and survival. The...
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Protein-Protein Docking Approach to GPCR Oligomerization
G-protein-coupled receptors (GPCRs), the largest family of human membrane proteins, play a crucial role in cellular control and are the target of...
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Protein
Proteins are the building block of the human body. It is recommended to consume 0.8 g of protein per kg of body weight. Quality is equally important:...
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Approaches to Backbone Flexibility in Protein–Protein Docking
Proteins are the fundamental organic macromolecules in living systems that play a key role in a variety of biological functions including...
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Computational Protein Binding
Why it is important to know this material? The computational approach to protein binding has become a crucial methodology in drug design and...
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Modulating gut microbiota using nanotechnology to increase anticancer efficacy of the treatments
Recent clinical and pathological evidence has implicated the gut microbiota as an interplay for regulating human body homeostasis, influencing...
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Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis
Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron disease. The disease is characterized by protein...
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METTL14 Suppresses Tumor Stemness and Metastasis of Colon Cancer Cells by Modulating m6A-Modified SCD1
Colon cancer (CC) is a malignant disease of the digestive tract, and its rising prevalence poses a grave threat to people's health....
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CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination
BackgroundMost patients with ovarian cancer (OC) treated with platinum-based chemotherapy have a dismal prognosis owing to drug resistance. However,...
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Cyclic AMP Responsive Element Binding Protein 3-like 4/AarF Domain Containing Kinase 5 Axis Facilitates Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells by Modulating the TGFβ Pathway
Cyclic AMP responsive element binding protein 3-like 4 (CREB3L4) has been reported as a transcription factor showing high expression in various...
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Protein Arginylation: Milestones of Discovery
Posttranslational modifications have emerged in recent years as the major biological regulators responsible for the orders of magnitude increase in...
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Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis
Although exosome therapy has been recognized as a promising strategy in the treatment of rheumatoid arthritis (RA), sustained modulation on RA...
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Plant Protein Hydrolysates as Healthier and Sustainable Nutraceutical
The pursuit of safer and more natural bioactive compounds has led researchers to explore plant protein hydrolysates as potential nutraceuticals....
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Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis
Osteoarthritis (OA) is a common degenerative joint disease that can cause severe pain, motor dysfunction, and even disability. A growing body of...
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The Role of Synthetic and Natural Biomaterials in Modulating the Autoimmune Response
The human immune system sketches an indispensable role in modulating disease advancement and maintaining tissue homeostasis. Conventionally, the...
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Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism
Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the...
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Whey protein hydrolysates improve high-fat-diet-induced obesity by modulating the brain–peripheral axis of GLP-1 through inhibition of DPP-4 function in mice
PurposeObesity is a growing global health concern. Recent literature indicates a prominent role of glucagon-like peptide-1 (GLP-1) in glucose...
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Advances in ECM Protein-Based Materials
Proteins are the main building blocks of cell structure that play a vital role in the development of cell skeletons, cell differentiation,...
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The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg
BackgroundPostmenopausal osteoporosis (PMO) is a chronic condition characterized by decreased bone strength. This study aims to investigate the...
