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The Nenitzescu Reaction in the Synthesis of New Abietane Diterpene Indoles
The new abietane diterpene indoles were synthesized by the Nenitzescu reaction of 1a,4a-dehydroquinopimaric acid and its methyl ester with...
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Synthesis and characterization of stimuli-responsive hydrogel based on starch and methyl-3-aminocrotonate: swelling and degradation kinetics
Focus of the present studies was to synthesize a novel pH sensitive and thermoresponsive hydrogel which may show swelling behavior suitable for drug...
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Polymeric Betaines: Synthesis, Characterization, and Application
This review summarizes mostly the literature data accumulated during the last decade on betaine-type polyampholytes. Synthetic pathways to...
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Zn/MCM-41-catalyzed unsymmetrical Hantzsch reaction and the evaluation of optical properties and anti-cancer activities of the polyhydroquinoline products
AbstractThe three-component Hantzsch condensation of various aryl aldehydes, dimedone, and methyl 3-aminocrotonate was investigated in the presence...
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Synthesis of oxindolyl-pyrimidines and oxindolyl-furopyrimidines from isatin-derived propargylic alcohols
AbstractA Brønsted acid-catalyzed reaction of 6-amino uracil and isatin-derived propargylic alcohols for the synthesis of a series of oxindole-fused...
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Synthesis of Polysubstituted Pyrroles by the Reaction of Enaminoketones, Arylglyoxals, and N,N-Dimethylbarbituric Acid
Novel pentasubstituted pyrroles containing a propanoic acid fragment in position 1 were obtained by the reaction of arylglyoxals, N , N dimethylbarbituri...
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Crystal Structure of Ethyl 2,4-Dimethyl-1-phenyl-6-thioxo-1,6-dihydropyrimidine-5-carboxylate: The Product from the Reaction of Ethyl 3-Aminocrotonate, Phenylisothiocyanate and Acetic Anhydride
AbstractThe crystal structure of ethyl 2,4-dimethyl-1-phenyl-6-thioxo-1,6-dihydropyrimidine-5-carboxylate ( 7 ) has been determined (monoclinic, P 2 1 / n,...
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Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via ...
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An aqueous hydrotropic solution as environmentally benign reaction medium for organic transformations: a short review
Hydrotropes are a class of amphiphilic molecules that significantly increase the solubility of organic compounds in water. However, it cannot form...
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Pyridines, Dihydropyridines and Piperidines: An Outline on Synthesis and Biological Activities
Since their inception, heterocyclic compounds are the pillar of medicinal chemistry research. Out of all the heterocyclic moiety pyridines,...
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Growing Impact of Ionic Liquids in Heterocyclic Chemistry
In the quest for replacing the conventional toxic organic solvents, a continual effort has been made in fabricating a solvent that is versatile,...
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Synthesis of New Thieno[2,3-b]pyridine Derivatives Based on Fused Thiophenes
AbstractConditions for the Gewald synthesis of 2-amino-5,5-dimethyl-4,7-dihydro-5 H -thieno[2,3- c ]pyrans from 2,2-dimethyltetrahydropyran-4-ones have...
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Hybrid Hydrogels for pH Indicator
Hybrid hydrogels were prepared by copolymerization of 2-hydroxyethyl methacrylate and diallyldimethylammonium chloride mixed with alginate,...
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Optimized hidden target screening for very polar molecules in surface waters including a compound database inquiry
Highly polar trace organic compounds, which are persistent, mobile, and toxic (PMT) or are very persistent and very mobile (vPvM) in the aquatic...
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Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity
Heterocyclization of furan-2-carbonyl isothiocyanate 1 with a variety of aliphatic and aromatic nitrogen nucleophiles resulted in the formation of a...
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An alternative approach to the synthesis of 5H-chromeno[4,3-b]pyridin-5-one system using the cleavage of 5H,9H-pyrano[2',3':5,6]chromeno[4,3-b]pyridine-5,9-diones with binucleophiles
Hantzsch reaction has been successfully employed for a one-step assembling of pyranopyridine fragment to produce 5 Н ,9 Н -pyrano[2',3':5,6]-...
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Three-component synthesis of tetrasubstituted pyrroles by condensation with amines and arylglyoxals
A one-pot three-component condensation for the synthesis of functionalized pyrroles from arylglyoxal hydrates, acetylacetone or acetoacetic ester,...
