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Synthetic Transformations of Lappaconitine
Synthetic transformations of lappaconitine, N -norlappaconitine, and N -deacetyllappaconitine are reviewed.
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New C-19 Lappaconitine Derivatives
Previously unknown C-19 lappaconitine derivatives were prepared via [3 + 2] cycloaddition reactions of a nitrone based on lappaconitine with...
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Carbamide Derivatives of Lappaconitine
Carbamide derivatives of lappaconitine were prepared via reactions of N -deacetyllappaconitine and N -20-norlappaconitine with potassium isocyanate,...
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New C-19-Substituted Lappaconitine Derivatives
New lappaconitine, N -deacetyllappaconitine, and lappaconine derivatives with C-19 C–C-bonded substituents were prepared from...
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Bromination of lappaconitine and N-desacetyllappaconitine
Bromination of lappaconitine with a KBr—H 2 O 2 mixture in 20% H 2 SO 4 , as well as with molecular Br 2 in either Py, CH 2 Cl 2 , CH 3 COOH, or DMSO did not...
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Oxidative Halogenation of Lappaconitine and N-Deacetyllappaconitine HCl and HBr in the Presence of H2O2
Oxidative halogenation of lappaconitine and N -deacetyllappaconitine HBr or HCl in the presence of H 2 O 2 in MeOH was associated upon bromination by N -20...
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Unexpected Products of the Reaction of Lappaconitine-Based Nitrone with N,N-Diethylallylamine
AbstractThe reaction of [3 + 2] cycloaddition of a lappaconitine-based nitrone with N , N -diethylallylamine is accompanied by the formation of two...
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Antiarrhythmic agents based on diterpenoid alkaloid lappaconitine. Protonation of N-deacethyllappaconitine in methanol solutions
The data on antiarrhythmic drugs based on diterpene alkaloid lappaconitine are summarized. N -Deacetyllappaconitine is the main metabolite of...
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Esterification of Lappaconine by Aromatic Acids
A series of new lappaconitine structural analogs were prepared via esterification of the lappaconine C-4 hydroxyl by aromatic acids.
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Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties
Alkaloids are a type of secondary metabolites that can be found in different parts of plants. This group of compounds is diverse and can be divided...
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A review on efforts for improvement in medicinally important chemical constituents inAconitum through biotechnological interventions
The genus Aconitum belongs to the family Ranunculaceae, is endowed with more than 350 species on the earth. Medicinally important aconitine type of...
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Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments
The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the...
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Photochemical and Photophysical Processes of N-Deacetyllappaconitine and Its Monohydrobromide in Aqueous Solutions
The photophysical and photochemical processes of N -deacetyllappaconitine (DAL) and its hydrobromide (DAL·HBr) in aqueous solutions were investigated....
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Physicochemical Approaches to the Study of the Antioxidant Activity of Glycyrrhizin
AbstractThe review presents an attempt to collect and systematize the available data on the antioxidant activity of glycyrrhizin obtained by various...
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