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A deep neural network: mechanistic hybrid model to predict pharmacokinetics in rat
An important aspect in the development of small molecules as drugs or agrochemicals is their systemic availability after intravenous and oral...
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Advanced Organotypic In Vitro Model Systems for Host–Microbial Coculture
In vitro model systems have been advanced to recapitulate important physiological features of the target organ in vivo more closely than the...
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Antioxidant and Antithrombotic Activities of Kenaf Seed (Hibiscus cannabinus) Coat Ethanol Extract in Sprague Dawley Rats
Oxidative stress has been implicated in deadly lifestyle diseases, and antioxidants from plant sources are the primary option in the treatment...
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Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals
The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of...
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Assessment of the Safety of Lactobacillus casei IMV B-7280 Probiotic Strain on a Mouse Model
Probiotics, in particular Lactobacillus (lactic acid bacteria, LAB) strains, are widely used in clinical practice. Despite that these probiotics have...
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The Potential of Fish Protein Hydrolysate Supplementation in Nile Tilapia Diets: Effects on Growth and Health Performance, Disease Resistance, and Farm Economic Analysis
Fish protein hydrolysate (FPH) has shown immense potential as a dietary protein supplement and immunostimulant in aquaculture, especially in Nile...
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Analytical method development for exploring pharmacokinetic profile of ursolic acid in rat tissues by high-performance thin-layer chromatography
A simple and rapid high-performance thin-layer chromatographic (HPTLC) determination of ursolic acid (UA) in tissue is necessary for its utilization...
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Teleost Fish as an Experimental Model for Vaccine Development
Advances in vaccine development depend on animal models to test innovative therapies. Recent studies have reported the successful introduction of...
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Aluminum fluoride-18-labelled indocyanine green as a potential PET imaging agent for hepatic function reserve
This study evaluated the potential of Al 18 F-labelled restrained complexing agent (RESCA)-ICG to assess hepatic function reserve on PET/CT imaging. [ 18 ...
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Quercetin: The Biological Effects, Chemical Steadiness, Metabolism, and Delivery Systems
One of the most well-known flavonoids, quercetin, has long been a part of the human diet. Numerous health advantages, including antioxidant,...
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The effect of Allium saralicum R. M. Fritsch nanocapsules in yogurt on type 2 diabetes in male rats: physicochemical characterization and pharmacodynamics assessment
To treat illness, people are increasingly turning to natural foods rather than pharmaceuticals. Herbal extracts with antioxidant and anti-diabetic...
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Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust
BackgroundThere has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to...
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Dietary Probiotic Bacillus licheniformis H2 Enhanced Growth Performance, Morphology of Small Intestine and Liver, and Antioxidant Capacity of Broiler Chickens Against Clostridium perfringens–Induced Subclinical Necrotic Enteritis
The reduction in the use of antibiotics in the poultry industry has considerably increased the appearance of Clostridium perfringens (CP) – induced...
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Schistosomicidal, hepatoprotective and antioxidant activities of the N-acetyl-L-cysteine and/or praziquantel in experimental acute mansonic schistosomiasis
Schistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and...
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Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats
This study investigates the therapeutic effect of petroleum ether fraction of Trigonella foenum-graecum L. (PE-TFG) seed extract in ovariectomized...
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Protective Effect of Levilactobacillus brevis Against Yersinia enterocolitica Infection in Mouse Model via Regulating MAPK and NF-κB Pathway
Although the use of the probiotic bacterium Lactobacillus for the treatment and prevention of diseases caused by various pathogenic bacteria has...
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Impact of dietary sucralose and sucrose-sweetened water intake on lipid and glucose metabolism in male mice
AimsOverconsumption of sugar-sweetened beverages (SSBs) is associated with an increased risk of metabolic disorders, including obesity and diabetes....
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Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model
BackgroundThe major safety concern of the clinical application of wild type FGF19 (FGF19 WT ) emerges given that its extended treatment causes...
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Pharmacokinetics and Metabolism of Phytochemicals Having Anti-obesity and Antidiabetic Activity
The pharmacokinetics and metabolic knowledge of natural medicine (phytochemicals and herbal formulations) are highly beneficial for clinical dose...
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Precision Nutrition and Metabolomics, a Model of Alzheimer’s Disease
Metabolomics offers unique insights into the interface between environment, host, and microbiome in the pathophysiology of disease. New metabolomics...