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3-Aminofuro[2,3-b]pyridines: Reaction with N-Chlorosuccinimide and Sodium Hypochlorite
AbstractThe reaction of aminoamides of the furo[2,3- b ]pyridine series with an aqueous solution of sodium hypochlorite and N -chlorosuccinimide was...
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Unsymmetrical Pyridoxal-Based Bisazomethines
AbstractThe reaction of equimolar amounts of pyridoxal and 1,2-propylenediamine leads to the formation of monoimine, which exists as a cyclic...
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Reactions of pyridoxal with aromatic diamines
Pyridoxal monoimines were obtained by the reaction of pyridoxal with aromatic diamines. A change in the ratio of the reagents or introduction of...
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Synthesis of New Furopyridines Containing Carbonyl Group in Alkyl Substituent
AbstractThe method was developed for the synthesis of previously unknown pyridoxal (vitamin B 6 ) derivatives, containing a carbonyl group and a...
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Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals
The use of Pd-catalyzed cross-coupling methods for the construction of C-C, C-N, and C-O bonds have increased exponentially over the years. The...
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Some Features of Phosphorylation and Benzoylation of Pyridoxal Imidazolidines
AbstractThe reactions of pyridoxal imidazolidines with diphenylchlorophosphine oxide, depending on the substituents nature in the imidazolidine ring,...
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Recent Developments in Medicinal and In Silico Applications of Imidazopyridine Derivatives: Special Emphasis on Malaria, Trypanosomiasis, and Tuberculosis
People from low-income countries are increasingly affected by neglected communicable diseases, and the health care system frequently overlooks their...
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Structural Modification of Pyridoxal. Synthesis and Evaluation of Anti-Infective Activity of New 4-Chloro- and 4-Alkyl(dialkyl)aminomethyl-2-hetaryl(hetaroyl)furo[2,3-c]pyridines
Abstract4-Hydroxymethyl-2-hetaryl(hetaroyl)furo[2,3- c ]pyridines, the products of furan cyclization of pyridoxal with acylmethyl- and...
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The synthesis of novel 1-hetarylmethylidene-4-sulfanylfuro-[3,4-c]pyridin-3(1H)-ones
1-Hetarylmethylidene-4-sulfanylfuro[3,4- c ]pyridin-3-ones were accessed from 4-thioxo-4,5-dihydrofuro[3,4- c ]pyridin-3(1 H )-one employing a condensation...
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Intramolecular 6-endo-dig-Cyclization of Ethyl 5-Aminomethyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate
The reaction of 5-aminomethyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylic acid ethyl ester with bases has given ethyl...
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Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones
The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series...
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Organometallic Approaches to [3.1.0] Bicycles in Process Chemistry
Within the field of process chemistry, all available methods of synthesis are typically considered for the preparation of complex targets. Early in...
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Pyridoxal Azomethine Salts
The reactions of 4-methylpiperazin-1-amine, 2-amino- and 4-aminomethylpiperidines with pyridoxal afforded the corresponding azomethines. Their...
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Synthesis, characterization and cytotoxicity of new nicotinonitriles and their furo[2,3-b]pyridine derivatives
AbstractThe present research work describes the synthesis of new series of nicotinonitrile ( 2 ) and furo[2,3- b ]pyridine ( 3 ) heterocycles bearing...
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Pyridoxal: A New Alkylating Agent in Reactions with Phenols and Polyphenols
A possibility to use pyridoxal as an alkylating agent in the reactions of electrophilic mono-, di-, and trisubstitution in the aromatic core of...
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Reactions of Pyridoxal with Heterocycles Containing Primary Amino Group
New nitrogen-containing derivatives of pyridoxal were obtained as a result of its reaction with various amines. The reactions with amines bearing a...
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The structure of products of phenacylation and subsequent (re)cyclizations of 3-acetyl-4,6-dimethylpyridin-2(1H)-one according to X-ray structural analysis
A novel phenacylation reaction of an acetylpyridone has been described for the first time, where isomeric O - and N -substitution products were formed...
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Chemistry of pyridoxine in drug design
Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of vitamin B 6 , which play exceptionally important biological...
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Reactions of pyridoxal with aromatic carboxylic acids in alcoholic medium
Reactions of pyridoxal with benzoic acid and its derivatives in alcoholic medium afforded alkoxyfuropyridinium salts with potential biological...
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Reactions of polyhydric phenols with nitrogen-containing acetals in the synthesis of polyphenols and heterocyclic compounds
The review systematizes and summarizes the data on the reactions of nitrogen-containing acetals with phenols. Both intra- and intermolecular...