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Membrane Ultrafiltration-Based Sample Preparation Method and Sheath-Flow CZE-MS/MS for Top-Down Proteomics
Mass spectrometry (MS)-based denaturing top-down proteomics (dTDP) identify proteoforms without pretreatment of enzyme proteolysis. A universal...
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Structure prediction, molecular simulations of RmlD from Mycobacterium tuberculosis, and interaction studies of Rhodanine derivatives for anti-tuberculosis activity
Tuberculosis is the most dangerous disease causing maximum deaths than any other, caused by single infectious agent. Due to multidrug resistant of Myco...
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Anaerobic biosynthesis of rhamnolipids by Pseudomonas aeruginosa: performance, mechanism and its application potential for enhanced oil recovery
BackgroundPseudomonas aeruginosa , the rhamnolipids-producer, is one of dominant bacteria in oil reservoirs. Although P. aeruginosa strains are...
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New trends in microbial gums production, patented technologies and applications in food industry
The market for microbial gums such as xanthan, gellan, dextran, and curdlan is continuously expanding, driven by their increasing application in...
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Synthesis of doxorubicin pro-drug nanoparticles based on poloxamer188 and studies on their in vivo bio-security and in vitro anti-tumor activities
The purpose of this study was to develop a novel glutathione (GSH)-responsible doxorubicin (DOX) pro-drug (poloxamer188-S-S-DOX, PSSD) nanoparticles...
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Mixed-phase weak anion-exchange/reversed-phase LC–MS/MS for analysis of nucleotide sugars in human fibroblasts
Nucleotide sugars (NS) fulfil important roles in all living organisms and in humans, related defects result in severe clinical syndromes. NS can be...
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Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system
CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting...
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Improving rhamnolipids production using fermentation-foam fractionation coupling system: cell immobilization and waste frying oil emulsion
This work focused on the development of an inexpensive carbon source and the improvement of the fermentation-foam fractionation coupling system. The...
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Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases
Mutations in protein kinases are often associated with the development of cancer, and application of mutant-specific inhibitors as therapeutic...
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Genome mining of Streptomyces sp. BRB081 reveals the production of the antitumor pyrrolobenzodiazepine sibiromycin
Employing a genome mining approach, this work aimed to further explore the secondary metabolism associated genes of Streptomyces sp. BRB081, a marine...
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Rhamnolipids from Pseudomonas aeruginosa in the Cleaning of Polluted Environments
The use of rhamnolipids produced by Pseudomonas aeruginosa constitutes an attractive and eco-friendly alternative in the remediation of polluted...
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Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
The growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the...
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Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants
Many neurodegenerative diseases feature misfolded proteins that propagate via templated conversion of natively folded molecules. However, crucial...
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Biosynthesis of β-Amino Acid-Containing Macrolactam Polyketides
β-Amino acid-containing macrolactam antibiotics are an important class of macrocyclic polyketides in Actinobacteria. These macrolactam antibiotics...
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Recyclable polythioesters and polydisulfides with near-equilibrium thermodynamics and dynamic covalent bonds
The accumulation of discarded petroleum-based plastics causes serious environmental crises. Currently, recyclable polymers with neutrality in...
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Genome mining of Pseudomonas spp. hints towards the production of under-pitched secondary metabolites
The recent advances in omics and computational analysis have enabled the capacity to identify the exclusive strain-specific metabolites and novel...
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Potential therapeutic targets for combating Mycoplasma genitalium
Mycoplasma genitalium (M. genitalium) has emerged as a sexually transmitted infection (STI) all over the world in the last three decades. It has been...
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Nucleotide und Nucleinsäuren
Nucleotide wurden erstmals als Bausteine der Nucleinsäuren gefunden. Sie sind in charakteristischer Weise aufgebaut und haben inzwischen einer ganzen...
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Role of Biosurfactants in Enzyme Production
A biosurfactant is described as a “biosurface active” compound synthesized by various microbes. The purified microbial form of biosurfactant is...
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Introduction
Phthalate plasticizers, such as dioctyl phthalate (DOP), di(iso-octyl) phthalate (DIOP), di(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP),...