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Silver-manganese nanocomposite modified screen-printed carbon electrode in the fabrication of an electrochemical, disposable biosensor strip for cystic fibrosis
A silver-manganese nanocomposite was successfully prepared by the urea hydrolysis method and used to detect chloride ions in sweat electrochemically....
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Guardians Turned Culprits: NETosis and Its Influence on Pulmonary Fibrosis Development
Idiopathic pulmonary fibrosis (IPF) is a debilitating, life-threatening irreversible lung disease characterized by the excessive accumulation of...
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Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects
It is reported that pulmonary fibrosis has become one of the major long-term complications of COVID-19, even in asymptomatic individuals. Currently,...
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Novel inhalation therapy in pulmonary fibrosis: principles, applications and prospects
Pulmonary fibrosis (PF) threatens millions of people worldwide with its irreversible progression. Although the underlying pathogenesis of PF is not...
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Extracellular vesicles from Lactobacillus druckerii inhibit hypertrophic scar fibrosis
BackgroundHypertrophic scars (HS) affect millions of people each year and require better treatment strategies. Bacterial extracellular vesicles (EVs)...
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Sweat chloride assay by inductively coupled plasma mass spectrometry: a confirmation test for cystic fibrosis diagnosis
The current guidelines for sweat chloride analysis identify the procedures for sweat collection, but not for chloride assay, which is usually...
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Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota
BackgroundCystic Fibrosis (CF) is an autosomal recessive disorder with life-threatening organ manifestations. 87% of CF patients develop exocrine...
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Recombinant Adeno-associated Viral Vectors Serotypes 6 and 9 are Able to Transduce Human Tracheal Epithelial Cells but Not Human Induced Pluripotent Stem Cells
Recombinant adeno-associated viruses (rAAVs) may be useful for the development of gene therapy for hereditary diseases. Patient-specific human...
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Deubiquitinase-targeting chimeras for targeted protein stabilization
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Recent Developments in the Treatment of Bacterial Pneumonia
Bacterial pneumonia acquired from either the community, hospital, ventilators, aspiration, or tuberculous organisms represents a threat to an...
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Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes
The convergent positioning of functional groups in biomacromolecules leads to good binding, catalytic and transport capabilities. Synthetic...
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CFTR and Cystic Fibrosis From Structure to Function
This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular...
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Modulation of glucose-related metabolic pathways controls glucose level in airway surface liquid and fight oxidative stress in cystic fibrosis cells
Direct and indirect evidences show that elevated glucose concentrations in airway surface liquid (ASL) promote lung infection by pathogens, playing a...
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Different choline supplement metabolism in adults using deuterium labelling
BackgroundCholine deficiency leads to pathologies particularly of the liver, brain and lung. Adequate supply is important for preterm infants and...
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Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles, universally exist in body fluids, as well as cell and...
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A topological switch in CFTR modulates channel activity and sensitivity to unfolding
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is essential to maintain fluid homeostasis in key organs. Functional...
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Aerosol-based antimicrobial photoinactivation in the lungs: an action spectrum study
Chronic lung infections are among the most diffused human infections, being often associated with multidrug-resistant bacteria. In this framework,...
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Scrutiny of Metal Ion Binding Sites in Different Alginate Lyases through In Silico Analysis
Alginate lyases are epitomized as prospective therapeutic mediators for treating Pseudomonas aeruginosa infections, particularly in the cystic...
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CFTR and Cystic Fibrosis
Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasians and appears mostly in childhood. The first medical reports of CF...