Search
Search Results
-
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive features, including precise...
-
Sensitive chemoselectivity of cellulose nanocrystal films
Cellulose nanocrystals (CNCs), self-assembled into a chiral nematic structure film, create an advanced platform for the fabrication of remarkable...
-
Counterintuitive chemoselectivity in the reduction of carbonyl compounds
The reactivity of carbonyl functional groups largely depends on the substituents on the carbon atom. Reversal of the commonly accepted order of...
-
Controlling catalyst activity, chemoselectivity and stereoselectivity with the mechanical bond
Mechanically interlocked molecules, such as rotaxanes and catenanes, are receiving increased attention as scaffolds for the development of new...
-
Amorphous Goethite as a Catalyst of Chemoselectivity Epoxidation of Alkenes by Hydrogen Peroxide
AbstractA metal-free catalytic system for chemoselective epoxidation of alkenes by hydrogen peroxide at room temperature has been developed. The...
-
Effect of the acyl-group length on the chemoselectivity of the lipase-catalyzed acylation of propranolol—a computational study
The selective N-acylation of 1,2-amino alcohols has been proposed to occur through the proton shuttle mechanism. However, the O-acetylation of...
-
Chemoselectivity of Nitroxylation of Cage Hydrocarbons
AbstractThe composition of reaction mixtures obtained by nitroxylation of 13 cage hydrocarbons with 100% nitric acid and its mixtures with acetic...
-
Stereoselective conjugate cyanation of enals by combining photoredox and organocatalysis
Precise control over the selectivity of a reaction is a fundamental target. While great advances have been obtained in achieving stereocontrol, the...
-
[2+1] Cycloaddition reaction of α-atlantone with m-CPBA in the light of experimental and MEDT quantum-chemical study
The two diastereoisomers of 6-(3,4-epoxy-4-methylcyclohexyl)-2-methylhepta-2,5-dien-4-one were synthesized in the [2+1] cycloaddition reaction of...
-
A para- to meta-isomerization of phenols
Phenols and their derivatives are ubiquitous in nature and critically important industrial chemicals. Their properties are intimately linked to the...
-
Recent progress in the reduction of benzene derivatives and their industrial applications
Cyclohexane (CHA), cyclohexene (CHE), and 1,4-cyclohexadiene (CHD) derivatives have a wide variety of applications and scope in synthetic and...
-
Mimicking hydrogen-atom-transfer-like reactivity in copper-catalysed olefin hydrofunctionalization
The renaissance of catalytic metal hydride hydrogen atom transfer (MHAT) offers advanced tools for radical chemistry on simple olefins. While 3 d ...
-
Rapid and chemoselective imidation of sulfides in aqueous buffer enabled by a novel guanidine-derived N-O reagent
Herein we report the facile synthesis of a series of novel N-O reagents and identify N ′-di-Boc- N ″-[(mesitylsulfonyl)oxy]-guanidine as an efficient...
-
Ni-catalyzed highly regio- and stereo-selective diborylative cyclization of 1,6-enynes with diboron reagent
The Ni-catalyzed highly selective diborylative cyclization of 1,6-enynes with diboron reagent has been developed. When pinB-Bdan was used, multiple...
-
Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C–H bond activation
The development of novel strategies to rapidly construct complex chiral molecules from readily available feedstocks is a long-term pursuit in the...
-
Biocatalytic enantioselective C(sp3)–H fluorination enabled by directed evolution of non-haem iron enzymes
Due to the scarcity of C–F bond-forming enzymatic reactions in nature and the contrasting prevalence of organofluorine moieties in bioactive...
-
Iridium and B(C6F5)3 co-catalyzed chemoselective deoxygenative reduction of tertiary amides: application to the efficient synthesis and late-stage modification of pharmaceuticals
The Vaska’s complex—tris(pentafluorophenyl)borane combination was found to be a highly efficient cooperative catalysis system for the hydrosilylative...
-
Domino Heck-Pericyclic Reactions
Palladium-catalyzed cross-coupling reactions and cycloadditions as well as electrocyclic transformations can efficiently be combined in one-pot...
-
Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors
Significant progress has been made in asymmetric synthesis through the use of transition metal catalysts combined with Lewis bases. However, the use...
-
Competition of (3+2) annulation and (3+2) cycloaddition in the reaction of alkenes with donor-acceptor cyclopropanes
Lewis acid-initiated reaction of (het)aryl-substituted donor-acceptor cyclopropanes with styrenes was studied. The initiation of the process by tin( IV ...