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Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer
Due to its complicated pathophysiology, propensity for metastasis, and poor prognosis, colon cancer is challenging to treat and must be managed with...
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Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma
BackgroundMiRNAs act as negative regulators of gene expression through target mRNA degradation or inhibition of its translation. In cancer, several...
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Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro
Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained...
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Chitosan-miRNA functionalized microporous titanium oxide surfaces via a layer-by-layer approach with a sustained release profile for enhanced osteogenic activity
BackgroundThe biofunctionalization of titanium implants for high osteogenic ability is a promising approach for the development of advanced implants...
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Methods for CPP Functionalization with Oligonucleotides
This Chapter summarizes the methods for CPP-conjugated oligonucleotideOligonucleotide-based agents with the potential to use as the...
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Bridged Nucleic Acids for Therapeutic Oligonucleotides
Recent developments in genetic technologies for genomic analysis, diagnostics, and therapeutics have revolutionary effects on medical science....
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Bridged Nucleic Acids for Therapeutic Oligonucleotides
Recent developments in genetic technologies for genomic analysis, diagnostics, and therapeutics have revolutionary effects on medical science....
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Nanoparticles mediated tumor microenvironment modulation: current advances and applications
The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered...
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Aptamer-Based Drug Delivery Systems
Recently, aptamer-based drug delivery systems (DDSs) emerged as attractive platforms for precise medicine by targeting to disease cells and reducing...
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Emerging Graphene-Based Nanomaterials for Cancer Nanotheranostics
Recent times, graphene and its derivatives have drawn considerable interest encompassing multi-domains to extend our understanding of the physical...
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Circ-MAN1A2 Contributes to the Acquired Resistance of Gefitinib by Binding to miR-409-3p to Induce TWIST1 Expression in Non-small-cell Lung Cancer
Gefitinib has been widely used as a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for non-small-cell lung cancer...
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Hsa_circ_0001165 Regulates the Malignant Phenotype and Angiogenesis of Prostate Cancer Cells through miR-654-3p/DDAH1
Prostate cancer (PCa) is one of the most common malignant tumors, with a high rate of metastasis and recurrence. Circular RNA_0001165 (circ_0001165)...
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Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles
Extracellular vesicles (EVs) have emerged as a promising platform for gene delivery owing to their natural properties and phenomenal functions, being...
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Characterization of miRNAs from sardine (Sardina pilchardus Walbaum, 1792) and their tissue-specific expression analysis in brain and liver
MicroRNAs are endogenous highly conserved short (~ 21 nucleotides) non-coding RNA molecules that play key roles in post-transcriptional gene...
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Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in...
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Methods for Molecular Imaging, Detection and Visualization of CPPs
In this chapter, the most frequentlyVisualization used methods for studies of CPP internalization, mechanismsMechanism and localization are...
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Using Electropolymerization-based Do** for the Electro- addressable Functionalization of a Multi-electrode Array Probe for Nucleic Acid Detection
Even though large number of individually addressable electrodes can be effectively assembled in a small area, electrochemical detection methods have...
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Construction of nanomaterials as contrast agents or probes for glioma imaging
Malignant glioma remains incurable largely due to the aggressive and infiltrative nature, as well as the existence of blood–brain-barrier (BBB)....
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Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms
Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and...
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miRNAs: A New Method for Erythroid Differentiation of Hematopoietic Stem Cells Without the Presence of Growth Factors
Micro RNAs (miRNAs) are a novel class of non-coding regulatory RNA molecules that contribute to post-transcriptional gene regulation. Recent studies...
