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LncRNA VPS9D1-AS1 Sponging miR-520a-5p Contributes to the Development of Uterine Corpus Endometrial Carcinoma by Enhancing BIRC5 Expression
The pattern of VPS9D1-AS1 expression and its effects on uterine corpus endometrial carcinoma (UCEC) remained unclear. VPS9D1-AS1, miR-520a-5p, and...
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MiR-125b-5p Targets MTFP1 to Inhibit Cell Proliferation, Migration, and Invasion and Facilitate Cell Apoptosis in Endometrial Carcinoma
MicroRNAs (miRNAs) are recognized as latent diagnostic, prognostic, and therapeutic biomarkers for endometrial carcinoma (EC). We attempted to...
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Transcription Factor STAT3-Activated LDHB Promotes Tumor Properties of Endometrial Cancer Cells by Inducing MDH2 Expression
The pathogenesis of endometrial cancer (EC) involves the regulation of lactate dehydrogenases. However, the role and mechanism of lactate...
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Immunological Roles of CCL18 in Pan‑Cancer and Its Potential Value in Endometrial Cancer
Endometrial cancer (EC) is one of the most prevalent malignancies in the female reproductive system. However, the potential functions and mechanisms...
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Prognostic and Immunotherapeutic Predictive Value of CAD Gene in Hepatocellular Carcinoma: Integrated Bioinformatics and Experimental Analysis
Hepatocellular carcinoma (HCC) is a common type of cancer that ranks first in cancer-associated death worldwide. Carbamoyl-phosphate synthetase 2,...
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Network Medicine-Based Analysis of Association Between Gynecological Cancers and Metabolic and Hormonal Disorders
Different metabolic and hormonal disorders like type 2 diabetes mellitus (T2DM), obesity, and polycystic ovary syndrome (PCOS) have tangible...
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Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients
Tank-binding kinase 1 (TBK1) is a multifunctional kinase having essential roles in cellular processes, autophagy/mitophagy, and selective clearance...
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Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers
The prevalence of cancer deaths globally and domestically is higher especially due to the deferment of diagnosis and lack of facilities for women's...
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The Impact of Transcriptional Profiling Cadherin Family and Therapeutic Approaches of Gastric Cancer: A Translational Outlook on Multi-omics Data Analysis
The classical cadherin gene has been linked to a variety of human malignancies, including gastric cancer. However, the link between cadherin genes...
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SIRT2 as a Potential Biomarker in Lung Adenocarcinoma: Implications for Immune Infiltration
SIRT2 play important roles in cell cycle and cellular metabolism in the development of non-small cell lung cancer (NSCLC), and SIRT2 exhibits its...
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Pan-Cancer Analysis Shows that KIFC2 is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Bladder Cancer
KIFC2 plays an important role in prostate cancer progression and chemotherapy resistance, but the mechanism of its involvement in other malignancies...
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NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
NKD inhibitor of WNT signaling pathway 2 (NKD2) is an emerging player in cancer onset and progression. Here, it was confirmed that THCA patients have...
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Prime Editing: An Emerging Tool in Cancer Treatment
Prime Editing is a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) based genome editing technique having promising potential in...
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Homology Modeling, Screening, and Identification of Potential FOXO6 Inhibitors Curtail Gastric Cancer Progression: an In Silico Drug Repurposing Approach
Gastric cancer is the world’s second leading cause of cancer-related fatalities, with the epidemiology changing over the previous several decades....
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Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry
We developed and validated a liquid chromatography high-resolution mass spectrometry method for the absolute quantification of 51 steroids for...
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Integration of Proteomics and Other Omics Data
In recent biomedical studies, multidimensional profiling, which collects proteomics as well as other types of omics data on the same subjects, is...
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Food–Drug Interactions and Nutraceuticals
Nutraceuticals are products that are present in food, which apart from providing nutritive value also act as potential drugs. They bestow...
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Natural Estrogenic Substances, Origins, and Effects
Some natural substances have been scientifically identified as estrogenic since the late 1930s when they were found to be deleterious at high doses...
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Safety of clomiphene citrate: a literature review
Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not?...
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Natural Estrogenic Substances, Origins, and Effects
Some natural substances have been scientifically identified as estrogenic since the late 1930s when they were found to be deleterious at high doses...