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A critical evaluation of ultrasensitive single-cell proteomics strategies
Success of mass spectrometry characterization of the proteome of single cells allows us to gain a greater understanding than afforded by...
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The tightest self-assembled ruthenium metal–organic framework combined with proximity hybridization for ultrasensitive electrochemiluminescence analysis of paraquat
Metal–organic frameworks (MOFs), as porous materials, have great potential for exploring high-performance electrochemiluminescence (ECL) probes....
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Amorphous hollow manganese silicate nanosphere oxidase mimic for ultrasensitive and high-reliable colorimetric detection of biothiols
Metal-based nanozymes with exceptional physicochemical property and intrinsic enzymatic properties have been widely used in industrial, medical, and...
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Droplet digital molecular beacon-LAMP assay via pico-injection for ultrasensitive detection of pathogens
A pico-injection-aided digital droplet detection platform is presented that integrates loop-mediated isothermal amplification (LAMP) with molecular...
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Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide
An ultrasensitive sandwich-type electrochemical immunosensor for pro-gastrin-releasing peptide (ProGRP) detection was constructed based on PtCu...
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Development of a separation platform comprising magnetic beads combined with the CRISPR/Cas12a system enabling ultrasensitive and rapid detection of miRNA-21
A separation platform has been developed mediated by a combination of magnetic beads and the CRISPR/Cas12a system to achieve ultrasensitive and rapid...
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Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays
Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved...
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Polydopamine-assisted aptamer-carrying tetrahedral DNA microelectrode sensor for ultrasensitive electrochemical detection of exosomes
BackgroundExosomes are nanoscale extracellular vesicles (30–160 nm) with endosome origin secreted by almost all types of cells, which are considered...
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A nanogap-enhanced SERS nanotag–based lateral flow assay for ultrasensitive and simultaneous monitoring of SARS-CoV-2 S and NP antigens
A lateral flow assay (LFA) strip based on dual 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB)–encoded satellite Fe 3 O 4 @Au (Mag@Au) SERS tags with nanogap...
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A High-Performance Electrochemical Analysis Platform for Ultrasensitive Detection of HTLV-1 DNA: Integrating Cascade Signal Amplification with λ-Exonuclease-Assisted Target Recycling and Enzyme Catalysis
Human T-cell lymphophilic virus type 1 (HTLV-1), the known retrovirus causing cancer in humans, is closely associated with adult T-cell...
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An ultrasensitive hairpin sensor based on g-C3N4 nanocomposite for the detection of miRNA-155 in breast cancer patient serum
Achieving the early diagnosis of breast cancer, through ultrasensitive detection of tumor marker miRNA-155, is a significant challenge. Therefore, an...
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Effect of perylene assembly shapes on photoelectrochemical properties and ultrasensitive biosensing behaviors toward dopamine
In this study, a photoelectrochemical (PEC) sensor based on perylene diimide derivatives (PDIs) was developed for the ultrasensitive quantification...
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Develo** an ultra-reproducible and ultrasensitive label-free nanoassay for L-methionine quantification in biological samples toward application in homocystinuria diagnosis
A novel, rapid, selective, ultrasensitive, and ultra-reproducible spectrofluorometric nanoassay was designed for the L-methionine quantification. A...
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Identification and ultrasensitive photoelectrochemical detection of LncNR_040117: a biomarker of recurrent miscarriage and antiphospholipid antibody syndrome in platelet-derived microparticles
The abnormal expression of long non-coding RNAs (LncRNAs) in platelet-derived microparticles (PMPs) is closely related to immune disorders and may...
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Photothermal enhanced fluorescence quenching of Tb-norfloxacin for ultrasensitive human epididymal 4 detection
A fluorescence quenching enhanced immunoassay has been developed to achieve ultrasensitive recognition of human epididymal 4 (HE4) modifying the...
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Electrochemical cytosensor utilizing tetrahedral DNA/bimetallic AuPd holothurian-shaped nanoparticles for ultrasensitive non-destructive detection of circulating tumor cells
As a real-time fluid biopsy method, the detection of circulating tumor cells (CTCs) provides important information for the early diagnosis, precise...
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Silver nano-reporter enables simple and ultrasensitive profiling of microRNAs on a nanoflower-like microelectrode array on glass
MicroRNAs (miRNAs) are small non-coding RNAs with ~ 22 nucleotides, playing important roles in the post-transcriptional regulation of gene...
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Ultrasensitive dynamic light scattering immunodetection of alpha-fetoprotein using heptamer-amplified nanoparticle crosslinking aggregation
A novel construction strategy is introduced for an ultrasensitive dynamic light scattering (DLS) immunosensor targeting alpha fetoprotein (AFP)....
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Lithium-electroactive peroxidase-like MnO2 nanomaterials as an ultrasensitive and selective sensing platform for carcinogenic 3,3′-diaminobenzidine and high-capacity lithium-ion batteries cathode materials
In this study, the lithium-electroactive peroxidase-like MnO 2 nanomaterials were utilized as ultrasensitive and selective sensing platforms for...
