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Phosphorylation of 5-Amino-1H-1,2,4-triazoles with Diethyl Phosphorochloridate
AbstractNew phosphorylated 5-amino-1 H -1,2,4-triazoles were obtained by the chemoselective reaction of diethyl phosphorochloridate with 5-amino-1 H -1,2...
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C(5)—H arylation of 1-substituted 1,2,4-triazoles with aryl halides under Pd/NHC catalysis
An efficient method for the synthesis of 1-substituted 5-aryl-1,2,4-triazoles by selective C—H arylation of 1-substituted 1,2,4-triazoles with...
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Synthesis and Extraction Properties of 4,5-Diphosphorylated Triazoles
AbstractA method for the synthesis of 4,5-diphosphorylated 1,2,3-triazoles has been developed and their extraction properties with respect to U(VI),...
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Triple Bond Species in the Synthesis of Oxa(thia)diazoles and Triazoles (A Review)
AbstractThis review summarizes advances in the synthesis of 1,3,4-oxadiazoles, 1,2,4-isoxadiazoles, thiadiazoles and triazoles based on compounds...
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Continuous preparation and reaction of nonaflyl azide (NfN3) for the synthesis of organic azides and 1,2,3-triazoles
Organic azides are widely used in organic synthesis. Continuous flow processing can be used to bypass their isolation, and can therefore be useful in...
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Synthesis, photophysical and DFT investigations on 1,2,3-triazoles linked to chalcone and chalco-pyrene
A library of chalco-pyrene linked 1,2,3-triazole hybrids containing both electron-donating and withdrawing groups were synthesized through CuAAC...
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Metal-Free Synthesis of 1,5-Disubstituted 1,2,3-Triazoles
AbstractThe main synthetic approaches to 1,5-disubstituted 1,2,3-triazoles are considered. It is shown that the cycloaddition of aryl azides to...
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Computational studies on CuAAC reaction mechanism with [CuX(PPh3)]; X = I, Br, Cl for the synthesis of 4- and 5-halo-1,2,3-triazoles
A complementary catalytic system was investigated for the [3 + 2] cycloaddition of azides and halo-alkynes. These are based on three copper complexes...
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Efficient synthesis of 3-aminocarbazoles from N-sulfonyl-1,2,3-triazoles and 2-alkenylindole
An efficient two-step protocol for the synthesis of 3-aminocarbazoles has been accomplished from N -sulfonyl-1,2,3-triazoles and 2-alkenylindoles. The...
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Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles
AbstractA series of chalcone-based 1,2,3-triazole compounds was synthesized Condensation of aldehydes and ketones results in the formation of...
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Nickel-Catalyzed N-Arylation of C-Amino-1,2,4-triazoles with Arylboronic Acids
AbstractNickel-catalyzed N-arylation of C -amino-1,2,4-triazoles with arylboronic acids was studied for the first time. An efficient catalytic system...
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Reaction of 1,2,4-Triazine-5-carbonitriles with 5-[(2-Hydroxyethyl)sulfanyl]- and 5-{[2-(2-Hydroxyethoxy)-ethyl]sulfanyl}-3-amino-1,2,4-triazoles1
AbstractThe solvent-free reaction of 1,2,4-triazine-5-carbonitriles with newly synthesized 5-[(2-hydroxyethyl)sulfanyl]- and...
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Thermal properties and decomposition mechanism of disubstituted fused 1,2,4-triazoles considered as potential anticancer and antibacterial agents
Thermal resistance is a very important parameter when assessing the therapeutic usefulness of potential pharmaceutics. Therefore, the thermal...
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Synthesis, Crystal Structure, Anticancer Evaluation and Hirshfeld Surface Analysis of Novel Antipyrine Gathered Bis-Triazoles as Breast Adenocarcinoma Inhibitors
AbstractA series of novel substituted antipyrine attached bis-triazoles 7 ( a-h ) were synthesized via coupling followed by click chemistry reaction....
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Potential role of hydrazinyl 1,2,4-triazoles derivatives as acetylcholinesterase inhibitors: synthesis, biological evaluation, kinetics mechanism and molecular docking and simulation studies
In the current study, total six hydrazinyl 1,2,4-triazoles derivatives ( 5a–5f ) are reported. A new series of pyridine substituted 1,2,4-triazoles was...
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An expedient heterogeneous catalyst for one-pot tandem synthesis of 1-aryl-1, 2, 3-triazoles through Huisgen 1,3-cycloaddition
In the present study, cellulose-supported Schiff base Cu(II) catalyst [(Cell-ThP-Cu(II))] has been developed, synthesized, and characterized by TGA,...
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Recent Investigation on Synthetic ‘Triazoles’ Scaffold as Potential Pharmacological Agents: A Comprehensive Survey
BackgroundTriazoles, a five-membered aromatic ring with three nitrogen atoms can effortlessly bind with a variety of enzymes and receptors in the...
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Rh(II)-catalyzed and non-catalytic synthesis of (Z)-ethene-1,2-diamines from 1-tosyl-1,2,3-triazoles and primary anilines
The reactions of 4-aryl-1-tosyl-1,2,3-triazoles with substituted primary 2- or 4-nitroanilines, catalyzed by dirhodium tetrapivalate were used to...
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Nano Au/TiO2 Catalyzed Click Synthesis of Novel 1,2,3-Triazoles from S-Propargyl-1,2,4-triazole: Antibacterial Activity, Toxicity, and Docking Analysis
AbstractA new series of 1,2,3-triazoles was synthesized by a titania-supported nano gold nanoparticles catalyzed 1,3-dipolar cycloaddition of...
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Synthesis of 1,4-disubstituted-1,2,3-triazoles using starch-functionalized copper (II) acetate as a recyclable heterogeneous catalyst in water
Copper (II) acetate is covalently anchored onto the surface of chemically modified starch and the resultant heterogeneous catalyst was investigated...
