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Generation of surrogate goldfish Carassius auratus progeny from common carp Cyprinus carpio parents
Surrogate broodstock technology can increase the production efficiency of commercially important fishes that are difficult to breed in confinement...
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Icosahedral gold nanoparticles decorated with hexon protein: a surrogate for adenovirus serotype 5
AbstractThe development of synthetic particles that emulate real viruses in size, shape, and chemical composition is vital to the development of...
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A Cell-free Protein Synthesis Method for the Detection of Heavy Metal Ions Using a Personal Glucose Meter
Heavy metal pollution of water can pose a serious threat to public health. Because pollution can occur at multiple stages of water distribution,...
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Catalytic length-controlled oligomerization with synthetic programmable templates
Nature uses templated length-controlled oligomerization to process genetic information. Templates that are DNA and RNA based and fully synthetic have...
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A numerical compass for experiment design in chemical kinetics and molecular property estimation
Kinetic process models are widely applied in science and engineering, including atmospheric, physiological and technical chemistry, reactor design,...
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Intact quantitative bioanalytical method development and fit-for-purpose validation of a monoclonal antibody and its related fab fragment in human vitreous and aqueous humor using LC-HRMS
Ranibizumab is an FDA-approved drug used to treat wet age-related macular degeneration (AMD), diabetic retinopathy, macular edema, and myopic...
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Finely tuned ionizable lipid nanoparticles for CRISPR/Cas9 ribonucleoprotein delivery and gene editing
Nonviral delivery of the CRISPR/Cas9 system provides great benefits for in vivo gene therapy due to the low risk of side effects. However, in vivo...
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In silico approach for the development of novel antiviral compounds based on SARS-COV-2 protease inhibition
The COVID-19 pandemic emerged in 2019, bringing with it the need for greater stores of effective antiviral drugs. This paper deals with the...
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Evolution of Transgenic Technology: From Random Transgenesis to Precise Genome Editing
New techniques in molecular biology help us for better understanding of biological processes. As biologists we resort to powerful approaches for...
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A Phagosomally Expressed Gene, rv0428c, of Mycobacterium tuberculosis Demonstrates Acetyl Transferase Activity and Plays a Protective Role Under Stress Conditions
Mycobacterium tuberculosis genome is composed of several hypothetical gene products that need to be characterized for understanding the physiology of...
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Molecularly imprinted polymers for selective extraction/microextraction of cancer biomarkers: A review
Over recent years, great efforts have been extensively documented in top scientific journals on the development of methods for early diagnosis,...
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Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants
Countless individuals have fallen victim to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have generated antibodies, reducing...
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Introduction
Molecular strain occurs when a molecule deviates from its ideal theoretical geometry. The strain is mainly classified into three types: steric strain...
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Detection of Mutations in Rifampin-Resistant Mycobacterium Tuberculosis by Short Oligonucleotide Ligation Assay on DNA Chips (SOLAC)
A new approach, a short oligonucleotide ligation assay on DNA chips (SOLAC) is developed to detect DNA mutations. The SOLAC approach can be carried...
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Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R
Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors....
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Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction
The combination of computational design and directed evolution could offer a general strategy to create enzymes with new functions. So far, this...
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Noncanonical Amino Acid Incorporation in Mice
Genetic code expansion enables in cellulo biosynthesis of curative proteins with enhanced specificity, improved stability, and even novel functions,...
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Nanopore DNA sequencing technologies and their applications towards single-molecule proteomics
Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost and portability. This...
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Enzymatic Synthesis of Base-Modified Nucleic Acids
Nucleic acids collectively play primordial functions, some of which are still barely understood, in all living organisms. DNA and RNA...
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Enzymatic Synthesis of Base-Modified Nucleic Acids
Nucleic acids collectively play primordial functions, some of which are still barely understood, in all living organisms. DNA and RNA...