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Multiarmed DNA jumper and metal-organic frameworks–functionalized paper-based bioplatform for small extracellular vesicle–derived miRNAs assay
Small extracellular vesicle–derived microRNAs (sEV-miRNAs) have emerged as promising noninvasive biomarkers for early cancer diagnosis. Herein, we...
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Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics
Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of...
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Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine
In this book chapter, we provide a comprehensive overview of the latest breakthroughs of delivery systems of CRISPR-Cas via extracellular vesicles...
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Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine
In this book chapter, we provide a comprehensive overview of the latest breakthroughs of delivery systems of CRISPR-Cas via extracellular vesicles...
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Advanced extracellular vesicle bioinformatic nanomaterials: from enrichment, decoding to clinical diagnostics
Extracellular vesicles (EVs) are membrane nanoarchitectures generated by cells that carry a variety of biomolecules, including DNA, RNA, proteins and...
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Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs
The profiling of small extracellular vesicle-associated microRNAs (sEV-miRNAs) plays a vital role in cancer diagnosis and monitoring. However,...
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Analysis of Extracellular Vesicle and Contaminant Markers in Blood Derivatives Using Multiple Reaction Monitoring
Extracellular vesicles (EVs) are naturally occurring membranous particles that can be isolated from blood and other biofluids. EVs have drawn...
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Human umbilical cord mesenchymal stromal cell small extracellular vesicle transfer of microRNA-223-3p to lung epithelial cells attenuates inflammation in acute lung injury in mice
BackgroundAcute lung injury (ALI), manifested as strong pulmonary inflammation and alveolar epithelial damage, is a life-threatening disease with...
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Single Extracellular Vesicle Analysis Using Droplet Microfluidics
Extracellular vesicles (EVs) are lipid-bound nanometer-sized vesicles released by all cell types that contain molecular payload such as proteins...
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Depletion of abundant plasma proteins for extracellular vesicle proteome characterization: benefits and pitfalls
Blood extracellular vesicles (EVs) play essential roles in cell–cell communication and their molecular cargo is a promising source of disease...
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Electrochemical Detection of Cancer Fingerprint: A Systematic Review on Recent Progress in Extracellular Vesicle Research from Lab to Market
Cancer is a major global health burden and accounts for the second-highest mortality rate around the world. Despite significant advances in cancer...
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Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte apoptosis
Osteoarthritis (OA) is a common joint disease caused by progressive articular cartilage degeneration and destruction. Currently, there are no...
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Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
BackgroundReduced supplies of oxygen and nutrients caused by vascular injury lead to difficult-to-heal pressure ulcers (PU) in clinical practice....
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Identification and evaluation of circulating small extracellular vesicle microRNAs as diagnostic biomarkers for patients with indeterminate pulmonary nodules
BackgroundThe identification of indeterminate pulmonary nodules (IPNs) following a low-dose computed tomography (LDCT) is a major challenge for early...
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Synergistic vesicle-vector systems for targeted delivery
With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology, challenges such as target specificity remain. The...
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Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-Free Fractions, and Cells
Cellular Communication Network (CCN) proteins are growth factors that play key roles in many pathophysiological events, including bone formation,...
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Protocol for Plasma Extracellular Vesicle and Particle Isolation and Mass Spectrometry-Based Proteomic Identification
Plasma extracellular vesicles and particles (EVPs) are enriched in biomolecules that reflect individuals’ physiological and pathological states....
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A Robust and Clinically Applicable Sample Preparation Protocol for Urinary Extracellular Vesicle Isolation Suitable for Mass Spectrometry-Based Proteomics
Urinary extracellular vesicles (uEVs) are a rich source of noninvasive protein biomarkers. However, for translation to clinical applications, an...
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A possible role of gas-phase electrophoretic mobility molecular analysis (nES GEMMA) in extracellular vesicle research
The emerging role of extracellular vesicles (EVs) as biomarkers and their envisioned therapeutic use require advanced techniques for their detailed...
