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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates
Several RNA binding proteins involved in membraneless organelles can form pathological amyloids associated with neurodegenerative diseases, but the...
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Development of a nanohybrid system by selenium nanoparticles and lysozyme amyloid fibrils with improved conductivity and antibacterial activity
Today, nanoparticles have promised a variety of applications in conjugation with biomolecules. Selenium nanoparticles (SeNPs) have shown to be...
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Fluorescent paper strip immunoassay with carbon nanodots@silica for determination of human serum amyloid A1
A fluorescent paper strip immunoassay in conjunction with carbon nanodots@silica (CND@SiO 2 ) as a label was developed for the quantitative...
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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer’s and Parkinson’s disease, can form different fibril structures...
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The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils
The maturation of liquid-like protein condensates into amyloid fibrils has been associated with several neurodegenerative diseases. However, the...
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Structure-specific amyloid precipitation in biofluids
The composition of soluble toxic protein aggregates formed in vivo is currently unknown in neurodegenerative diseases, due to their ultra-low...
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Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system
Disaggregation of amyloid fibrils is a fundamental biological process required for amyloid propagation. However, due to the lack of experimental...
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Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils
Protein aggregates, hereunder amyloid fibrils, can undergo a maturation process, whereby early formed aggregates undergo a structural and...
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Molecularly imprinted sensor based on poly-o-phenylenediamine-hydroquinone polymer for β-amyloid-42 detection
A sensitive and selective molecularly imprinted polymer (MIP) sensor was developed for the determination of amyloid-β (1–42) (Aβ 42 ). The glassy...
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Exposure of combination of environmental pollutant, lead (Pb) and β-amyloid peptides causes mitochondrial dysfunction and oxidative stress in human neuronal cells
Exposure to the environmental pollutant lead (Pb) has been linked to Alzheimer’s disease (AD), in which mitochondrial dysfunction is a pathological...
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Human Serum Albumin Fibril Formation in the Presence of Ligands with Different Affinity
AbstractThe effect of binding of several organic ligands with different affinities on the kinetics of fibril formation of human serum albumin under...
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A comprehensive mini-review on amyloidogenesis of different SARS-CoV-2 proteins and its effect on amyloid formation in various host proteins
Amyloidogenesis is the inherent ability of proteins to change their conformation from native state to cross β-sheet rich fibrillar structures called...
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Measuring the Size and Spontaneous Fluctuations of Amyloid Aggregates with Fluorescence Correlation Spectroscopy
Bacterial amyloids decorate the cell surface of many bacteria by forming functional amyloid fibers. These amyloids have structural and biochemical...
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Advances in sample preparation and HPLC–MS/MS methods for determining amyloid-β peptide in biological samples: a review
Alzheimer’s disease (AD), a neurological disorder, is a major public health concern and the most common form of dementia. Its typical symptoms...
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The Inhibition Mechanisms of Three Structurally Different Salvianolic Acids on the Non-Enzymatic Glycation of Bovine Serum Albumin
The antiglycation mechanisms of three structurally different salvianolic acids (Sals) including salvianolic acid A (Sal-A), salvianolic acid B...
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Dual-mode transfer response based on electrochemical and fluorescence signals for the detection of amyloid-beta oligomers (AβO)
An aptamer sensor has been developed utilizing a dual-mode and stimuli-responsive strategy for quantitative detection of AβO (amyloid-beta...
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Anti-Amyloid β Aggregation Activity and Cell Viability Effect of Betacyanins from Red Pitahaya (Hylocereus polyrhizus) for Alzheimer’s Disease
Betacyanin-rich extract from red beet ( Beta vulgaris ) was recently reported to inhibit amyloid β (Aβ) aggregation, a main pathological event in...
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Competitive fluorescent immunoassay for the ultrasensitive determination of amyloid beta peptide1-42 based on Ag@SiO2@N, S-GQD nanocomposites
AbstractA competitive fluorescent immunoassay is described for the ultrasensitive determination of amyloid beta peptide1-42 (Aβ1-42), a biomarker for...
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Supramolecule self-assembly synthesis of amyloid phenylalanine-Cu fibrils with laccase-like activity and their application for dopamine determination
Laccases are multicopper proteins for dioxygen-involved oxidation of a broad spectrum of organic compounds. I Novel amyloid-like phenylalanine-Cu...
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Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition
BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for...
