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A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric...
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Microbial Proline Racemase–Proline Dehydrogenase Cascade for Efficient Production of d-proline and N-boc-5-hydroxy-l-proline from l-proline
d -proline and N -boc-5-hydroxy- l -proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient...
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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
Serine hydrolases have important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using...
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Next-Generation Therapies for Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM), which has been considered a pandemic due to its growing pervasiveness in the world population, is associated with...
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Comparative study of HPLC-DAD and HPTLC for the simultaneous determination of a new multitarget antidiabetic ternary mixture in combined tablets
Qternmet XR® (FDA approval, May 2019) is a multitarget anti-diabetic drug combination composed of metformin (MET), saxagliptin (SAX) and...
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Reaction of Adamantan-1-ol with Lower Alcohols in the Presence of CuBr2
AbstractThe reaction of adamantan-1-ol with lower alcohols (methanol, ethanol) in the presence of water and an equimolar amount of CuBr 2 (with...
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Synthesis of (Thio)semicarbazones Combining Adamantane and 3,7-Dimethyloctyl Fragments
AbstractA series of new (thio)semicarbazones containing adamantane and 3,7-dimethyloctyl fragments was synthesized. The configuration of imine bond...
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Synthesis and Structural Study of Cytisinylphenylacetic Acid Nitriles
Nitriles of stereoisomeric cytisinylarylacetic acids were synthesized by reacting cytisine with aromatic aldehydes in the presence of acetone...
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Synthesis of Hantzsch poly-substituted pyridines containing adamantyl moiety
A one-step procedure has been developed for the synthesis of new Hantzsch poly-substituted pyridines from a three-component reaction of N -(adamantan-1...
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How Effective are Gliflozins as DPP-4 Inhibitors? A Computational Study
AbstractDPP-4 inhibition is an incretin-based therapy that works on the principle of stop** the degradation of glucagon-like polypeptide-1 (GLP-1)...
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Development and validation of stability indicating HPTLC method for simultaneous estimation of Dapagliflozin and Linagliptin
For the treatment of Type 2 Diabetes Mellitus, Dapagliflozin selectively inhibits the sodium-glucose co-transporter-2, while Linagliptin...
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Synthesis and Reactions of Allylic Azides of the Adamantane Series
AbstractA mixture of a nucleophilic substitution product and its isomeric azide resulting from [3,3]-sigmatropic rearrangement was obtained as a...
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Bioactive Compounds from Food and Their Applications in the Treatment of Type 2 Diabetes
The occurrence of insulin and glucose metabolism disorders (collectively referred to as Diabetes), are increasing globally with expectations that...
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Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects
Catalytic enantioselective Strecker reactions on an achiral substrate using sub-stoichiometric amounts of a chiral catalyst represent an evolving key...
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Development of scoring-assisted generative exploration (SAGE) and its application to dual inhibitor design for acetylcholinesterase and monoamine oxidase B
AbstractDe novo molecular design is the process of searching chemical space for drug-like molecules with desired properties, and deep learning has...
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Association between intuitive eating and health outcomes in outpatients with type 2 diabetes: a cross-sectional study
PurposeTo evaluate the association between intuitive eating and health outcomes in patients with type 2 diabetes in a cross-sectional study.
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Nano-fluorescent quantum dots as substrates for determination of ribavirin in pharmaceuticals and human plasma as well as monitoring of its kinetic interaction with salmon sperm DNA
Ribavirin (RIB) was successfully determined by fluorescence spectroscopy upon its quenching to environment friendly phosphorus and nitrogen co-doped...
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Formation of dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from Jack Bean (Canavalia ensiformis (L.) DC.) sprout in simulated digestion
Bean sprouts are potential plant proteins that produce DPP-IV inhibitory peptides. These peptides must be stable and active in the brush border...
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Fused azoloazines with antidiabetic activity
The purpose of this review is to summarize drugs containing an azoloazine moiety and exhibiting antidiabetic activity. The review includes...
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Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XIV. N-[(Adamantan-1-yl)(phenyl)methyl]-N′-substituted Ureas and Symmetrical Bis-ureas
AbstractA procedure has been developed for the synthesis of rac -1-[isocyanato(phenyl)methyl]adamantane from rac -2-(adamantan-1-yl)-2-phenylacetic...
