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Activation of human STING by a molecular glue-like compound
Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to...
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Extracellular matrix-degrading STING nanoagonists for mild NIR-II photothermal-augmented chemodynamic-immunotherapy
Regulation of stimulator of interferon genes (STING) pathway using agonists can boost antitumor immunity for cancer treatment, while the rapid plasma...
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Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A
The microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not...
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Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression
Plant-derived nanovesicles (PDNVs) have been proposed as a major mechanism for the inter-kingdom interaction and communication, but the effector...
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Cocktail strategy based on a dual function nanoparticle and immune activator for effective tumor suppressive
BackgroundImmune checkpoint inhibitor-mediated immunotherapy cannot be carried out on a large scale clinically due to its low universality. In recent...
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Polymer-based synthetic oncolytic virus-like nanoparticles for cancer immunotherapy
Oncolytic viruses have emerged as new powerful therapeutic agents for cancer therapy by specifically lysing cancer cells while activating innate...
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Nanocarriers for effective delivery: modulation of innate immunity for the management of infections and the associated complications
Innate immunity is the first line of defense against invading pathogens. Innate immune cells can recognize invading pathogens through recognizing...
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Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both...
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Adjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions
Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a...
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All-Rounder Liposomes in Cancer Immunotherapy: Strategies and Design Applications of Engineered Liposomal Nanomaterials
Cancer is a major health problem worldwide, which is responsible for more than 10 million deaths annually. Cancer treatment has traditionally been...
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Cancer Therapy-Induced Inflammation and Its Consequences
The inflammatory process often modifies the natural history of cancers. There is broad evidence that chronic inflammatory responses, associated with,...
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Chemistry of Cyclic Dinucleotides and Analogs
Cyclic dinucleotides (CDNs) are a class of macrocyclic natural product consisting of two nucleotides linked via two phosphodiester linkages. For...
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Manganese-derived biomaterials for tumor diagnosis and therapy
Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading to the emergence of various...
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One-Pot Synthesis of 3-Carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic Acids
AbstractA one-pot synthesis of 3-carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic acids has been developed via the reaction of...
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Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity
SLC15A4 is an endolysosome-resident transporter linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like...
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Biomaterials as Antigen Delivery Carrier for Cancer Immunotherapy
Since immunotherapy provides an opportunity to treat metastatic and disseminated tumors, it has become a major treatment strategy for cancer....
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Chemistry of Cyclic Dinucleotides and Analogs
Cyclic dinucleotides (CDNs) are a class of macrocyclic natural product consisting of two nucleotides linked via two phosphodiester linkages. For...
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Escherichia coli small molecule metabolism at the host–microorganism interface
Escherichia coli are a common component of the human microbiota, and isolates exhibit probiotic, commensal and pathogenic roles in the host. E. coli ...
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Nanomaterials: small particles show huge possibilities for cancer immunotherapy
With the economy's globalization and the population's aging, cancer has become the leading cause of death in most countries. While imposing a...
