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Synthetic strategies of pyran derivatives by multicomponent reaction (MCR) approach
Six-membered oxygen-containing ring system has captivated the interest of synthetic chemists due to its broad spectrum of biological and...
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Overview of Medical and Biological Applications of Indium(III) Complexes
Indium(III) complexes are versatile species that emit Auger electrons which made them a choice for a wide range of biological and medical...
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Combination of polylactide with cellulose for biomedical applications: a recent overview
This review summarizes the use of cellulose and polylactide for medical applications with particular emphasis on modern dressings. Although classic...
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Synthesis and Biological Importance of Pyrazole, Pyrazoline, and Indazole as Antibacterial, Antifungal, Antitubercular, Anticancer, and Anti-inflammatory Agents
N-heterocycles have always gained greater attention among the scientific community. Indole, indazole, pyrrole, pyrazole, pyrazoline, pyridine,...
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The Biology and Chemistry of Microsomal Prostaglandin E Synthase (mPGES) - I Inhibitors for Cancer Biomedicine
According to WHO, Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. The predicted global cancer burden...
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Synthesis of novel carbazole hydrazine-carbothioamide scaffold as potent antioxidant, anticancer and antimicrobial agents
BackgroundCarbazole-based molecules containing thiosemicarbazide functional groups are recognized for their diverse biological activities,...
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Bioactivity-Guided Fractionation and Identification of Bioactive Molecules: A Basic Method in Drug Discovery
The process of discovering new medications is called as drug discovery. From the ancient period to modern age, there has been a significant...
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Role of Computational Modelling in Drug Discovery for HIV
With over 36 million people currently living with HIV, HIV/AIDS continues to have devastating effects on human health worldwide. Viral resistance to...
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Enzymes and Enzyme Inhibitors from Apocynaceae Plants
Enzymes have been extensively utilised in numerous sectors from last few decades. Recent years have seen a rise in interest in and demand for enzymes...
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A new anticancer derivative of the natural alkaloid, theobromine, as an EGFR inhibitor and apoptosis inducer
The epidermal growth factor receptor (EGFR) plays a key role in the pathogenesis of cancers of different types. It has been shown that EGFR and...
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Multicomponent reactions through pristine and modified chitosans: current status and future prospects
Multicomponent reactions (MCRs) have emerged, in the last few years, as an important tool for the development of more sustainable processes in modern...
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Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold
Backgroundpenta-1,4-diene-3-one oxime ether and quinazolin-4(3 H )-one derivatives possess favorable agricultural activities. Aiming to discover novel...
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Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes
Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over...
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Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design
Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation or inhibition is considered a potential powerful tool in...
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In silico screening of epidermal growth factor receptor (EGFR) in the tyrosine kinase domain through a medicinal plant compound database
The unregulated epidermal growth factor receptor tyrosine kinase (ErbB1-TK or EGFR-TK) protein is involved in the proliferation of more than 50% of...
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Spinal Muscular Atrophy: Current Therapeutic Strategies
Proximal spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by death of motor neurons in the spinal cord. SMA is caused...
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Traditional Medicine for Memory Enhancement
In traditional practices of medicine, numerous plants have been used to alleviate memory impairment both in healthy individuals and those with...
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Chemical probes for histone-modifying enzymes
The histone-modifying enzymes that catalyze reversible lysine acetylation and methylation are central to the epigenetic regulation of chromatin...
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Rescue of Folding Defects in ABC Transporters Using Pharmacological Chaperones
The ATP-binding cassette (ABC) family of membrane transport proteins is the largest class of transporters in humans (48 members). The majority of ABC...