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Printed Biosensors for the Detection of Alzheimer’s Disease Based on Blood Biomarkers
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, and early diagnosis plays a crucial role in its prevention and treatment. In recent...
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Recent Advances in Photoelectrochemical Sensing of Alzheimer’s Biomarkers
Alzheimer's disease (AD) is the most prevalent cause of dementia, affecting one in nine people aged 65 years and older worldwide. Pathological...
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Assay of Biomarkers for Alzheimer’s Disease by Surface Plasmon Resonance
Alzheimer’s disease (AD) is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment. Early diagnosis...
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Disease-related biomarkers as experimental endpoints in 3D skin culture models
The success of in vitro 3D models in either recapitulating the normal tissue physiology or altered physiology or disease condition depends upon the...
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Progressive expansion of albumin adducts for organophosphorus nerve agent traceability based on single and group adduct collection
Protein adducts are important biological targets for traceability of organophosphorus nerve agents (OPNAs). Currently, the recognized biomarkers that...
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Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes and indicating the health status of humans. Abnormal...
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Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles, universally exist in body fluids, as well as cell and...
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Identification of Diagnostic Biomarkers for Compensatory Liver Cirrhosis Based on Gut Microbiota and Urine Metabolomics Analyses
Liver cirrhosis is one of the most prevalent chronic liver disorders with high mortality. We aimed to explore changed gut microbiome and urine...
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Entropy-driven reactions for controlling CRISPR/Cas12a and constructing an electrochemical biosensor for cardiac biomarkers detection
An electrochemical biosensor is reported for controlling CRISPR/Cas12a activity through the utilization of entropy-driven reactions, alongside the...
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An Interaction Network Driven Approach for Identifying Cervical, Endometrial, Vulvar Carcinomic Biomarkers and Their Multi-targeted Inhibitory Agents from Few Widely Available Medicinal Plants
Differently expressed genes (DEGs) across cervical (CC), endometrial (EC), and vulvar carcinoma (VC) may serve as potential biomarkers for these...
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LncRNA-TUG1 Downregulation is Correlated with the Development of Progressive Chronic Kidney Disease Among Patients with Congestive Heart Failure
TUG1 is an lncRNA that plays a critical role in kidney injury. Our preliminary sequencing analysis showed altered TUG1 expression in both congestive...
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Detection of COVID-19-related biomarkers by electrochemical biosensors and potential for diagnosis, prognosis, and prediction of the course of the disease in the context of personalized medicine
As a more efficient and effective way to address disease diagnosis and intervention, cutting-edge technologies, devices, therapeutic approaches, and...
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Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer’s disease: from current to future challenges
Increasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the...
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Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer
Immunotherapy is an effective treatment for esophageal cancer (ESCA) patients. However, there are no dependable markers for predicting prognosis and...
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Magnetic separation and concentration of Aβ 1–42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample
BackgroundAlzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and...
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Single-Cell Sequencing Data Analysis Unveiled HDAC1 as the Therapeutic Target for Chronic Pancreatitis
Chronic pancreatitis (CP) as a progressive inflammatory disorder, remains untreatable. The novel treatment strategy for CP is imperative. We...
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System Biology Research to Advance the Understanding of Canine Cancer
Dogs are easy to train and have far superior olfactory abilities than humans, making them suitable for a wide range of tasks. Therapy dogs are used...
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Integrated spatial metabolomics and network pharmacology to explore the pharmacodynamic substances and mechanism of Radix ginseng-Schisandra chinensis Herb Couple on Alzheimer’s disease
Radix ginseng and Schisandra chinensis have been extensively documented in traditional Chinese medicine (TCM) for their potential efficacy in...
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DIGE-Based Biomarker Discovery in Blood Cancers
Cancer of blood or bone marrow-derived cells dysregulates normal hematopoiesis and accounts for over 6% of all cancer cases annually. Proteomic...
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Nanodiagnostics: New Tools for Detection of Animal Pathogens
The twenty-first century carries several challenges to the world in the areas of human healthcare and veterinary science. In the last few decades,...