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Molecular Dynamics Simulations Reveal Novel Interacting Regions of Human Prion Protein to Brucella abortus Hsp60 Protein
The distinctive morphology characteristics of microfold cells (M cells) allow the vaccine antigen not only to interact with immune cells directly,...
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A structural basis for prion strain diversity
Recent cryogenic electron microscopy (cryo-EM) studies of infectious, ex vivo, prion fibrils from hamster 263K and mouse RML prion strains revealed a...
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Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils
Amyloidogenesis, self-propagation of protein or peptide monomers to amyloid fibrils, has been linked to incurable pathogenesis of neurodegenerative...
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Metal Ions Bound to Prion Protein Affect its Interaction with Plasminogen Activation System
Prion diseases are a group of neurodegenerative diseases, which can progress rapidly. Previous data have demonstrated that prion protein (PrP)...
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Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system
Disaggregation of amyloid fibrils is a fundamental biological process required for amyloid propagation. However, due to the lack of experimental...
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Homodimeric complexes of the 90–231 human prion: a multilayered computational study based on FMO/GRID-DRY approach
The molecular interaction properties and aggregation capabilities disclosed by PrP-E200K, a pathogenic mutant of the human prion protein, were...
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Short disordered protein segment regulates cross-species transmission of a yeast prion
Soluble prion proteins contingently encounter foreign prion aggregates, leading to cross-species prion transmission. However, how its efficiency is...
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Challenges of Protein-Protein Docking of the Membrane Proteins
Despite the recent advances in the determination of high-resolution membrane protein (MP) structures, the structural and functional characterization...
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Biosynthesis Application and Modification of Protein Fiber
Wool, silk, and cashmere are natural fibers, proteins which are developed of condensed alpha-amino acids found in animal sources. They possess unique...
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Up-Regulated Proteins Have More Protein–Protein Interactions than Down-Regulated Proteins
Microarray technology has been successfully used in many biology studies to solve the protein–protein interaction (PPI) prediction computationally....
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Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that determine their driving forces for phase separation. Here we...
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Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry
Microglia are brain-resident phagocytic cells, considered to be the innate immune cells of the central nervous system. Microglia respond to both...
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Propagation of Distinct α-Synuclein Strains Within Human Reconstructed Neuronal Network and Associated Neuronal Dysfunctions
Aggregated alpha-synuclein (α-Syn) in neurons is a hallmark of Parkinson’s disease (PD) and other synucleinopathies. Recent advances (1) in the...
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Hampering the early aggregation of PrP-E200K protein by charge-based inhibitors: a computational study
A multilayered computational workflow was designed to identify a druggable binding site on the surface of the E200K pathogenic mutant of the human...
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Aptamer-based Membrane Protein Analysis and Molecular Diagnostics
Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities. Analysis of membrane proteins is...
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Programmable Self-Assembling Protein Nanomaterials: Current Status and Prospects
Protein-based nanomaterials are increasingly engineered as platforms for applications in biomanufacturing, for biomedical purposes, and as structural...
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Aldehyde Production as a Calibrant of Ultrasonic Power Delivery During Protein Misfolding Cyclic Amplification
The protein misfolding cyclic amplification (PMCA) technique employs repeated cycles of incubation and sonication to amplify minute amounts of...
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Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation has important implications for analysing cellular function,...
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Determinants that enable disordered protein assembly into discrete condensed phases
Cells harbour numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These...
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SESNet: sequence-structure feature-integrated deep learning method for data-efficient protein engineering
Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate...
