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Isolable iminium ions as a platform for N-(hetero)aryl piperidine synthesis
Piperidines are prevalent throughout Food and Drug Administration-approved drugs and current drug candidates, and thus robust methods for preparing...
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An Integrated Computational Approaches for Designing of Potential Piperidine based Inhibitors of Alzheimer Disease by Targeting Cholinesterase and Monoamine Oxidases Isoenzymes
The study aimed to evaluate the potential of piperidine-based 2H chromen-2-one derivatives against targeted enzymes, i.e., cholinesterase’s and...
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Development of Spiro[chromane-2,4′-piperidine]-4(3H)-one Compounds in the Field of Medicinal Chemistry Research (A Review)
AbstractIn the recent past, spiro[chromane-2,4′-piperidine]-4(3 H )-one has been proven as one of the most valued scaffolds utilized by several...
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CHARACTERIZATION, CRYSTAL STRUCTURE, ANTICANCER AND ANTIOXIDANT ACTIVITY OF NOVEL N-(2-OXO-2-(10H-PHENOTHIAZIN-10-YL) ETHYL)PIPERIDINE-1-CARBOXAMIDE
AbstractA new compound, N-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)piperidine-1-carboxamide (PTZ–PIP) was synthesized and characterized by Fourier...
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Design, synthesis, molecular docking and in silico ADMET investigations of novel piperidine-bearing cinnamic acid hybrids as potent antimicrobial agents
In order to combat microbial infections and to address the issue of multi-drug resistance, a class of novel piperidine-bearing cinnamic acid hybrids 4a –...
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4,4′-Trimethylenedipiperidine, a safe and greener alternative for piperidine, catalyzed the synthesis of N-methyl imines
A practical and facile synthesis of various N -methyl imines, versatile scaffolds, was conducted at 85 °C using 4,4′-trimethylenedipiperidine as a...
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Investigation of the hydrogen bonded host‧‧‧guest and guest‧‧‧guest interactions present in complexes of a polyaromatic wheel-and-axle host compound with dioxane, morpholine, piperidine and pyridine
1,4-Bis(diphenylhydroxymethyl)benzene ( H ), a host compound possessing wheel-and-axle geometry, was found to possess host ability for dioxane (DIO),...
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Recent investigation on heterocycles with one nitrogen [piperidine, pyridine and quinoline], two nitrogen [1,3,4-thiadiazole and pyrazole] and three nitrogen [1,2,4-triazole]: a review
Heterocycles form by far the largest of classical divisions of organic chemistry and are of immense importance biologically and industrially, and...
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Structural and thermochemical studies of pyrrolidine borane and piperidine borane by gas electron diffraction and quantum chemical calculations
The gaseous structures, thermochemical properties and dehydrogenation reaction energy profiles of the borane complexes of pyrrolidine and piperidine...
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Conformational Aspects and Interaction Studies of Heterocyclic Drugs
Drug discoveries require the iterative synthesis—along with structural studies—of numerous individual analogues of biologically and medicinally...
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A practical synthesis for the key intermediate of apixaban
Apixaban is a highly potent, selective, and efficacious inhibitor of blood coagulation factor Xa. A practical and efficient process has been...
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Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes
The synthesis of functionalized nitrogen heterocycles is integral to discovering, manufacturing and evolving high-value materials. The availability...
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Reactivity of Tetraphenoxy-Substituted Phthalocyanines in Acid–Base Reactions with Organic Bases
AbstractThe interaction of tetra-4-(2-methoxyphenoxy)phthalocyanine and tetra-4-(3-methoxyphenoxy)phthalocyanine with pyridine, 2-methylpyridine,...
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1,3-Elimination of HBr from dimethyl (2S,4RS)-4-bromo-N-phthaloylglutamate under the action of bases: a theoretical study
Stereospecific reactions of dimethyl (2 S ,4 RS )-4-bromo- N -phthaloylglutamate with KOH, triethylamine, and piperidine affording dimethyl ( Z )-1-phthalimid...
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Kinetically Controlled Acid–Base Interaction of Tetra-4-chloro-tetra-5(5-methyl-2-isopropylphenoxy)phthalocyanine with Nitrogen-Containing Organic Bases
AbstractThe interaction of the first synthesized tetra-4-chloro-tetra-5(5-methyl-2-isopropylphenoxy)phthalocyanine with pyridine, 2-methylpyridine,...
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Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents
AbstractA novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2 H -1,2,4-triazole-3(4 H )-thione core have been...
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[Difluoro(pyridinyl)methyl]phosphonates
An efficient and convenient method for the synthesis of all isomeric [difluoro(pyridinyl)methyl]phosphonates based on electrophilic fluorination of...
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Selective Hydrogenation of Pyridine and Derivatives of It on Bimetallic Catalysts Modified with Chitosan
AbstractA study is performed of the catalytic properties of bimetallic nanoparticles based on palladium and a base metal (silver or copper) supported...
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2-Amino-4-(1-piperidine) pyridine exhibits inhibitory effect on colon cancer through suppression of FOXA2 expression
The present study was aimed to investigate the effect of 2-amino-4-(1-piperidine) pyridine on migration and invasion of colon cancer cells. Treatment...
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Synthesis of Substituted Thienopyrimidinones Based on Ethyl 2-Amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate
AbstractPreviously synthesized ethyl 2-benzamido-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylates were cyclized to 2-aryl-3-aminothieno[2,3- d ]pyrimidin-4(1...