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Phage-based delivery systems: engineering, applications, and challenges in nanomedicines
Bacteriophages (phages) represent a unique category of viruses with a remarkable ability to selectively infect host bacteria, characterized by their...
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Mobile CRISPR-Cas9 based anti-phage system in E. coli
Escherichia coli is one of the most important microbial cell factories, but infection by bacteriophages in the environment may have a huge impact on...
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Phage Display as a Medium for Target Therapy Based Drug Discovery, Review and Update
Phage libraries are now amongst the most prominent approaches for the identification of high-affinity antibodies/peptides from billions of displayed...
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A highly sensitive electrochemiluminescence method for abrin detection by a portable biosensor based on a screen-printed electrode with a phage display affibody as specific labeled probe
Abrin is a highly toxic ribosome-inactivating protein, which could be used as a biological warfare agent and terrorist weapon, and thus needs to be...
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Research Progress of ARTP Mutagenesis Technology Based on Citespace Visualization Analysis
Atmospheric and room temperature plasma (ARTP) mutagenesis technology has been developed rapidly in recent years because of its simple operation,...
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Poly(indole-5-carboxylic acid)/reduced graphene oxide/gold nanoparticles/phage-based electrochemical biosensor for highly specific detection of Yersinia pseudotuberculosis
Yersinia pseudotuberculosis is an enteric bacterium causing yersiniosis in humans. The existing Yersinia pseudotuberculosis detection methods are...
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Laser-Assisted Recovery of On-Chip Phage Viral DNA for Phage Fluorescence Immunoassay Microchip
Laser-assisted recovery of on-chip phage viral DNA was demonstrated. Optomechanical energy conversion was utilized to shear off a part of a microchip...
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Diverse applications and development of aptamer detection technology
Aptamers have received extensive attention in recent years because of their advantages of high specificity, high sensitivity and low immunogenicity....
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Quantitative Label-free Determination of Thrombin Using a Chemically-modified M13 Virus-electrode Interface
The use of affinity peptide displaying on the surface of M13 phage has emerged as a promising alternative to antibody-based detection methods owing...
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Design of Sponge-like Chitosan Wound Dressing with Immobilized Bacteriophages for Promoting Healing of Bacterially Infected Wounds
Application of wound dressings loaded with antimicrobial agents is considered a viable option to reduce wound bacterial colonization and prevent...
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Development of competitive and noncompetitive lateral flow immunoassays for pendimethalin using synthetic peptides
Peptidomimetic and anti-immunocomplex peptides can be easily isolated from phage display libraries, and can be used as alternatives to chemical...
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Immobilization of a broad host range phage on the peroxidase-like Fe-MOF for colorimetric determination of multiple Salmonella enterica strains in food
A broad host range phage-based nanozyme (Fe-MOF@SalmpYZU47) was prepared for colorimetric detection of multiple Salmonella enterica strains. The...
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A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer
BackgroundGastric cancer represents a highly lethal malignancy with an elevated mortality rate among cancer patients, coupled with a suboptimal...
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Trends and Challenges in Enzyme Technology
Several major developments took place in the field of biocatalysis over the past few years. These include the invention of directed evolution...
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Harnessing protein sensing ability of electrochemical biosensors via a controlled peptide receptor–electrode interface
BackgroundCathepsin B, a cysteine protease, is considered a potential biomarker for early diagnosis of cancer and inflammatory bowel diseases....
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Biotin-labelled peptidomimetic for competitive time-resolved fluoroimmunoassay of benzothiostrobin
In recent years, more and more functional peptide ligands have been identified from phage display libraries and served the immunoassay of small...
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Evolution of Transgenic Technology: From Random Transgenesis to Precise Genome Editing
New techniques in molecular biology help us for better understanding of biological processes. As biologists we resort to powerful approaches for...
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New Tools for Streamlined In Vivo Homing Peptide Identification
In vivo peptide-phage display is an unbiased technique for map** of the vascular diversity and identification of homing peptides. This chapter is...
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Enhancing the Therapeutic Potential of Extracellular Vesicles Using Peptide Technology
Extracellular vesicles are lipid-bilayer-enclosed nanoparticles present in the majority of biological fluids that mediate intercellular...
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Identification of a novel family B DNA polymerase from Enterococcus phage IME199 and its overproduction in Escherichia coli BL21(DE3)
BackgroundIdentification and characterization of novel, faithful and processive DNA polymerases is a driving force in the development of DNA...
