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Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
BackgroundOxytetracycline which is derived from Streptomyces rimosus , inhibits a wide range of bacteria and is industrially important. The...
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Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers
BackgroundNatural products are a valuable source of biologically active compounds that have applications in medicine and agriculture. One...
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Morphological-metabolic analysis in Streptomyces rimosus microparticle-enhanced cultivations (MPEC)
Streptomyces produce a broad spectrum of biologically active molecules such as oxytetracycline and rimocidin, which are widely used in human and...
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Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis
BackgroundChelocardin (CHD) exhibits a broad-spectrum antibiotic activity and showed promising results in a small phase II clinical study conducted...
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Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps
Rishirilides are a group of PKS II secondary metabolites produced by Streptomyces bottropensis Gö C4/4. Biosynthetic studies in the past have...
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Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases
Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are...
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Results
The aim of the work was to activate antibiotic biosynthetic gene cluster expression of prioritized genome-sequenced actinomycetes with the help of...
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Study on a two-component signal transduction system RimA1A2 that negatively regulates oxytetracycline biosynthesis in Streptomyces rimosus M4018
Biosynthesis of secondary metabolites in actinobacteria is regulated by complex regulatory mechanisms on responding environmental changes. In this...
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Increasing Demeclocycline Production in Streptomyces aureofaciens by Manipulating the Expression of a Novel SARP Family Regulator and Its Genes
Demeclocycline (DMCTC), a tetracycline derivative antibiotic produced by Streptomyces aureofaciens , has attracted attention owing to its high...
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Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin
BackgroundMithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus . Its biosynthesis gene cluster has...
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Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S
BackgroundThe anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising...
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Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment
Although celebrating its golden jubilee, rapamycin’s importance keeps increasing by the day. Starting as a promising antifungal agent, then as a...
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Mining for Biosynthetic Gene Clusters in Actinobacteria Genomes Via Bioinformatics Tools
Genome mining using next-generation sequencing (NGS) technologies and bioinformatics tools opens the way to understand secondary metabolite...
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Advances in Nanomaterial-microbe Coupling System for Removal of Emerging Contaminants
Emerging contaminants are characterized by toxicity, environmental durability, and bioaccumulation. How to effectively remove them has attracted...
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Tetracycline antibiotics
Tetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics, which are effective against plague, cholera,...
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Polyketides
During the evolution of the plant species, several biochemical mechanisms have been raised as adaptation pathways to external abiotic and biotic...
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Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A
β-Amino acid-containing macrolactams represent a structurally diverse group of bioactive natural products derived from polyketides; however we are...
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Benign Synthesis of Cobalt Oxide Nanoparticles Containing Red Algae Extract: Antioxidant, Antimicrobial, Anticancer, and Anticoagulant Activity
Eco-friendly synthesis of Cobalt oxide nanoparticles (Co 3 O 4 NPs) was assessed by the aqueous extract of red algae and their utilization as...
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Engineering Streptomyces albulus to enhance ε-poly-L-lysine production by introducing a polyphosphate kinase-mediated ATP regeneration system
Backgroundε-Poly-L-lysine (ε-PL) is a natural and safe food preservative that is mainly produced by filamentous and aerobic bacteria Streptomyces...
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Microbial Battling of Fire Blight Disease on Pome Fruits
Erwinia amylovora (Burrill) causal agent of fire blight is one of the most destructive diseases that limits especially apple, pear, and quince...