Search
Search Results
-
First- and Second-Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy
Currently, a number of biologically active nucleoside analogues are extensively used as antiviral, anticancer, antiparasitic, and antibacterial...
-
First and Second Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy
Currently, a number of biologically active nucleoside analogues are extensively used as antiviral, anticancer, antiparasitic, and antibacterial...
-
Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress
ContextCalcium-dependent signaling in plants is responsible for several major cellular events, including the activation of the salinity-responsive...
-
Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments
Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis ( Mtb ). In addition, the emergence...
-
Efficient production of guanosine in Escherichia coli by combinatorial metabolic engineering
BackgroundGuanosine is a purine nucleoside that is widely used as a raw material for food additives and pharmaceutical products. Microbial...
-
Novel kinase platform for the validation of the anti-tubercular activities of Pelargonium sidoides (Geraniaceae)
BackgroundPelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented...
-
Histological and proteome analyses of Microbacterium foliorum-mediated decrease in arsenic toxicity in Melastoma malabathricum
Arsenic (As) is an increasing threat across the globe, widely known as a non-threshold carcinogen, and it is reaching harmful values in several areas...
-
Polymer complexes: LXXIX—synthesis, characterization, geometrical structures, biological activity and molecular docking studies of azo dye complexes
Polymer complexes of 5,5ʹ-{(1E, 1Eʹ)-1,4-phenylenebis(diazene-2,1-diyl)}bis(quinoline-8-ol) (H 2 L) with Cu(II), Co(II), Ni(II), Mn(II) and UO 2 (II)...
-
Cell-Free Production and Regeneration of Cofactors
Cofactors, such as adenosine triphosphate, nicotinamide adenine dinucleotide, and coenzyme A, are involved in nearly 50% of enzymatic reactions and...
-
Enzymatic Synthesis of Nucleoside Triphosphates and Deoxynucleoside Triphosphates by Surface-Displayed Kinases
Nucleoside triphosphates and deoxynucleoside triphosphates are important biochemical molecules. In this study, recombinant Escherichia coli that...
-
De novo engineering riboflavin production Bacillus subtilis by overexpressing the downstream genes in the purine biosynthesis pathway
BackgroundBacillus subtilis is widely used in industrial-scale riboflavin production. Previous studies have shown that targeted mutagenesis of the...
-
A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is...
-
Recent Advances in Rapid Screening Methods for Glycosyltransferases
Glycosyltransferases (GTs) are a diverse group of enzymes widely distributed in nature that catalyze the transfer of glycosyl moieties from activated...
-
β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin
Caprazamycin is a nucleoside antibiotic that inhibits phospho- N -acetylmuramyl-pentapeptide translocase (MraY). The biosynthesis of nucleoside...
-
Model-based Inference of Gene Expression Dynamics from Sequence Information
A dynamic model of prokaryotic gene expression is developed that makes considerable use of gene sequence information. The main contribution arises...
-
Synthesis, Characterization and Biological Activity of Transition Metals Schiff Base Complexes Derived from 4,6-Diacetylresorcinol and 1,8-Naphthalenediamine
The tridentate Schiff base ligand was prepared via condensation of 4,6-diacetylresorcinol and 1,8-naphthalenediamine in 1:1 molar ratio using...
-
Integrated mRNA and small RNA sequencing reveals post-transcriptional regulation of the sesquiterpene pathway in Santalum album L. (Indian sandalwood)
Key messageIn sandalwood, negative pattern of regulation by miRNAs was documented in key genes from the sesquiterpene pathway, with cytochrome P450...
-
Thermostable in vitro transcription-translation compatible with microfluidic droplets
BackgroundIn vitro expression involves the utilization of the cellular transcription and translation machinery in an acellular context to produce one...
-
Characterization of Two Polyphosphate Kinase 2 Enzymes Used for ATP Synthesis
Enzymes used for adenosine triphosphate (ATP) synthesis play important roles in energy-dependent cascade reactions in vitro. In this study, two novel...
-
Catalyst-free late-stage functionalization to assemble α-acyloxyenamide electrophiles for selectively profiling conserved lysine residues
Covalent probes coupled with chemical proteomics represent a powerful method for investigating small molecule and protein interactions. However, the...
