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Nanosuspension – A Novel Drug Delivery System via Nose-to-Brain Drug Delivery
NanosuspensionNanosuspensions administration via the nasal routeNasal route of administration appears to be an effective pathway of...
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Different Strategies for Nose-to-Brain Delivery of Small Molecules
The intranasal (IN) route of drug administration has emerged as an alternative route over the systemic (oral and parenteral) drug delivery to the...
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Nose-to-Brain Delivery of Peptides and Proteins
The fact that BBB is an important obstacle in drug delivery to the brain has revealed the need o try alternative drug administration routes. One of...
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Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride
The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier...
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Challenges in Targeting Nasal Passage and Nose-to-Brain Delivery via Nanoemulsions
Nasal drug delivery has been considered an important approach for brain targeting since the last decade. The intranasal route has gained attention as...
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Functionalized Nanoparticles in Drug Delivery: Strategies to Enhance Direct Nose-to-Brain Drug Delivery via Integrated Nerve Pathways
Nose-to-brain drug delivery system is becoming a desirable alternative approach to conventional drug delivery systems used for the treatment of...
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Intranasal Nose-to-Brain Drug Delivery via the Olfactory Region in Mice: Two In-Depth Protocols for Region-Specific Intranasal Application of Antibodies and for Expression Analysis of Fc Receptors via In Situ Hybridization in the Nasal Mucosa
A region-specific catheter-based intranasal administration method was successfully developed, established, and validated as reported previously. By...
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Biomedical Applications of Nanocarriers in Nasal Delivery
Non-invasive drug delivery is an emerging way to target a wide range of therapeutics. One of them, i.e., the nasal drug delivery has shown promising...
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Factors Affecting the Design of Nasal Drug Delivery System
Over the recent years, many strategies have improved the delivery of bioactive agents to the brain, improving the treatment of several pathologies....
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An Overview on Nanocarriers for Nasal Delivery
Nasal delivery has come up as a promising approach to deliver diverse therapeutic agents including small drug molecules to biomacromolecules like...
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Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis
Ferroptosis plays a critical role in ischemic stroke, and anti-ferroptosis strategies were regarded as potentially effective measures. Based on...
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Novel Mucoadhesive Polymers for Nasal Drug Delivery
Nasal drug administration is attractive noninvasive approach to rapidly achieve local or systemic effects of small molecular drugs, proteins, and...
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Pharmacological and Clinical Problems with Special Focus on Nasal Drug Delivery
The production of medications has seen many advancements. More diseases can now be managed or even treated and a variety of symptoms can be...
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Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN)
The blood–brain barrier (BBB) is the major barrier for brain drug delivery and limits the treatment options for central nervous system diseases. To...
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Niosomes-Based Drug Delivery in Targeting the Brain Tumors Via Nasal Delivery
Targeting tumors has always been a herculean task. Moreover, the presence of blood brain barrier (BBB) acts as a physical barrier and restricts the...
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Biopolymer Aerogels as Nasal Drug Delivery Systems
AbstractProtein (eggwhite) and chitosan aerogel microparticles characterized by low density, developed morphology, high specific surface area, high...
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Nasal Delivery of Micro and Nano Encapsulated Drugs
Drug encapsulation in nanoparticles and microparticles has been shown to be a promising application for nasal drug delivery. Drug encapsulation and...
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Potential Targeting Sites to the Brain Through Nasal Passage
Delivery to the central nervous system (CNS) has posed a major challenge in both therapeutics and diagnostics. Although nose-to-brain delivery has...
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Biobased Nanomaterials in Drug Delivery
Biobased nanomaterials have emerged as a pivotal element in modern drug delivery, garnering substantial attention within scientific research. These...
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Drug Delivery Systems for Cartilage
A dense network of extracellular matrix and lack of vascularization pose a major challenge in the delivery of therapeutics in the cartilage. Recent...