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In-Vitro Dissolution Study of Solid Dispersion Adsorbate of Nateglinide by Eco-Friendly Liquid Chromatography-Tandem Mass Spectrometric Method through Harmonized Approach of White Analytical Chemistry and Analytical Quality by Design
PurposeNateglinide, a member of the meglitinide class, is used as an oral antihyperglycemic agent to treat non-insulin-dependent diabetes mellitus....
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Analysis of Hypoglycemic Drugs by Liquid Chromatography-Tandem Mass Spectrometry
A rapid and simple method to measure oral hypoglycemic agents is essential in the evaluation of a patient with spontaneous hypoglycemia. As a result,...
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Identification of Potential Insulinotropic Cytotoxins from Indian Cobra Snake Venom Using High-Resolution Mass Spectrometry and Analyzing Their Possible Interactions with Potassium Channel Receptors by In Silico Studies
Snake venoms are a potential source of bioactive peptides, which have multiple therapeutic properties in treating diseases such as diabetes, cancer,...
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Response surface optimization of a vortex-assisted dispersive liquid–liquid microextraction method for highly sensitive determination of repaglinide in environmental water by HPLC/UV
A vortex-assisted dispersive liquid–liquid microextraction (DLLME) method, mated to chemometrics and combined with HPLC/UV detection was optimized...
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Drug Delivery Through Niosomes: A Comprehensive Review with Therapeutic Applications
Nanocarrier based formulations are increasing due to significant advantages over traditional formulations. They have shown potential in improvement...
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Dispersive Liquid–Liquid Microextraction
Dispersive liquid–liquid microextraction (DLLME) was initially described as an effective sample preparation technology in 2006. However, researchers...
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Multipurpose RP-HPLC Method for Simultaneous Estimation of Fixed-Dose Combinations of Anti-diabetic Drugs: Integrating Green, Economical, and Robust Approaches with Design of Experiments and White Analytical Chemistry
BackgroundMetformin hydrochloride is a common anti-diabetic medication, frequently prescribed in fixed-dose combinations for diabetes treatment....
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Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus
Diabetes mellitus (DM) type 2 is amongst the most common chronic diseases, being responsible for various problems in humans and contributing to...
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Simultaneous Determination of Selected Antidiabetic Pharmaceutical Drugs as Adulterants in Herbal Medicines Sold in Kenya Using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS)
Herbal medicines are usually marketed as natural products with multiple beneficial health claims. However, several studies have established that...
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Stability of co-Amorphous Solid Dispersions: Physical and Chemical Aspects
AbstractDrug amorphization is one of the major approaches in pharmaceutical sciences to improve the solubility and dissolution rate of poorly...
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Experimental and Computational Insights into Gangronema latifolium Leaf Compounds as GLP-1 Receptor Agonists
The International Diabetes Federation reported that in 2021, 6.7 million deaths globally were linked to diabetes. Ethnomedicinal and scientific...
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Support Vector Models-Based Quantitative Structure–Retention Relationship (QSRR) in the Development and Validation of RP-HPLC Method for Multi-component Analysis of Anti-diabetic Drugs
This work emphasized the use of the quantitative structure–retention relationship (QSRR) approach in the prediction retention time of anti-diabetic...
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A Critical Review on Role of Available Synthetic Drugs and Phytochemicals in Insulin Resistance Treatment by Targeting PTP1B
AbstractInsulin resistance (IR) is a condition of impaired response of cells towards insulin. It is marked by excessive blood glucose, dysregulated...
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Advanced Oral Sustained-Release Drug Delivery Systems for Older Patients
Oral drug delivery remains the route of preference in the general population due to the convenience of administration. Older adults have unique and...
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Molecular insights of anti-diabetic compounds and its hyaluronic acid conjugates against aldose reductase enzyme through molecular modeling and simulations study—a novel treatment option for inflammatory diabetes
ContextChronic inflammation is a risk factor for diabetes, but it can also be a complication of diabetes, leading to severe diabetes and causing many...
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The effect of l-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial
PurposePolycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-age women. Insulin resistance and dyslipidemia are linked...
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Poly(vinyl alcohol) membranes-inspired heterocyclic compounds for different applications: synthesis and characterization
Chemical modification of poly(vinyl alcohol) (PVA) with different monomers is a convention method for the development of its properties. In this...
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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved...
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Processing and Interpretation of Analytical Data with a High Degree of Uncertainty
AbstractSome analytical problems, which are often considered incorrect for objective reasons, are considered. The main of these reasons is an...
