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Gram-negative rough mutants used as test bacteria can increase sensitivity of direct bioautography
Currently, the antimicrobial activity of essential oils (EOs) is an outstanding research field due to antibiotic resistance of microorganisms....
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Backbone assignment and inhibitor binding studies of IL-33 mutants by NMR spectroscopy
Interleukin-33 (IL-33) is an IL-1 family protein that induces a type-2 immune response. IL-33 is constitutively expressed in epithelial cells and...
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In silico design of multipoint mutants for enhanced performance of Thermomyces lanuginosus lipase for efficient biodiesel production
BackgroundBiodiesel, an emerging sustainable and renewable clean energy, has garnered considerable attention as an alternative to fossil fuels....
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Mutation Significance and Assessment: Mutation Types and Selection of Mutants, Importance in Microbial Technology
A mutation refers to a change in the nucleic acid sequence within an organism’s genome. Mutations are essential for evolution to occur and play an...
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Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants
KRAS is the most frequently mutated oncogene in solid cancers, and inhibitors that specifically target the KRAS-G12C mutant were recently approved...
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Molecular recognition of SARS-CoV-2 spike protein with three essential partners: exploring possible immune escape mechanisms of viral mutants
ObjectiveThe COVID-19 epidemic is raging around the world, with the emergence of viral mutant strains such as Delta and Omicron, posing severe...
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Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology
Lysine-based post-translational modification (PTM) such as acylation, acetylation, deamination, methylation, SUMOylation, and ubiquitination has...
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Induction of Oxidative Stress in Sirtuin Gene-Disrupted Ashbya gossypii Mutants Overproducing Riboflavin
AgHST 1 and AgHST3 genes encode sirtuins that are NAD + -dependent protein deacetylases. According to previous reports, their disruption leads to the...
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Biochemical and biophysical properties of the novel ALS-linked hSOD1 mutants: an experimental study accompanied by in silico analysis
Familial amyotrophic lateral sclerosis (fALS) is a neurodegenerative disorder; approximately 20% are caused by dominant mutations in the gene...
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The Functional Study of Response Regulator ArlR Mutants in Staphylococcus Aureus
Staphylococcus aureus is a major cause of hospital-associated infections worldwide. The organism’s ability to form biofilms has led to resistance...
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A high-throughput dual system to screen polyphosphate kinase mutants for efficient ATP regeneration in L-theanine biocatalysis
ATP, an important cofactor, is involved in many biocatalytic reactions that require energy. Polyphosphate kinases (PPK) can provide energy for...
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Isolation and Screening of High-Yielding α-Amylase Mutants of Bacillus subtilis by Heavy Ion Mutagenesis
To improve fermentative production of α-amylase, heavy-ion mutagenesis technology was used to irradiate Bacillus subtilis ( B. subtilis ) to obtain the...
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Metabolomic response to high light from pgrl1 and pgr5 mutants of Chlamydomonas reinhardtii
Chlamydomonas (C.) reinhardtii metabolomic changes in cyclic electron flow-dependent mutants are still unknown. Here, we used mass spectrometric...
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Integrative transcriptome and proteome analyses of Trichoderma longibrachiatum LC and its cellulase hyper-producing mutants generated by heavy ion mutagenesis reveal the key genes involved in cellulolytic enzymes regulation
BackgroundThe major challenge of facing the efficient utilization of biomass is the high cost of cellulolytic enzyme, while the Trichoderma...
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Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants
Fibroblast growth factor receptor (FGFR) dysregulation is involved in a variety of tumorigenesis and development. Cholangiocarcinoma is closely...
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Impact of cell wall polysaccharide modifications on the performance of Pichia pastoris: novel mutants with enhanced fitness and functionality for bioproduction applications
BackgroundPichia pastoris is a widely utilized host for heterologous protein expression and biotransformation. Despite the numerous strategies...
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Identification of novel resources for panicle blast resistance from wild rice accessions and mutants of cv. Nagina 22 by syringe inoculation under field conditions
Panicle blast is the most severe type of rice blast disease. Screening of rice genotypes for panicle blast resistance at the field level requires an...
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Spontaneous Reactivation of OPC-Inhibited BChE Mutants: Modeling of Mechanisms
AbstractThe mechanism of the reactivation reaction of the double mutant butyrylcholinesterase (BChE) double mutantAsn322Glu/Glu325Gly, inhibited by...
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Metabolic analysis of Schizochytrium sp. mutants with high EPA content achieved with ARTP mutagenesis screening
Eicosapentaenoic acid (EPA) belonged to the ω-3 series of polyunsaturated fatty acids and had physiological functions lipid as regulating blood lipid...
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Discrimination of deletion to point cytokine mutants based on an array of cross-reactive receptors mimicking protein recognition by heparan sulfate
Differential sensing of proteins based on cross-reactive arrays and pattern recognition is a promising technique for the detection and identification...
