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Macrophage-Targeted Nanomedicines
Macrophages are versatile cells of the innate immune system responsible for the control and progressions of a variety of autoimmune inflammatory,...
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M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived...
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UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury
Macrophages polarized to the M2 subtype after spinal cord injury (SCI) are beneficial for promoting neurological recovery. The crosstalk between...
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Development of finely tuned liposome nanoplatform for macrophage depletion
BackgroundImmunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously...
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Nanotube patterning reduces macrophage inflammatory response via nuclear mechanotransduction
The inflammatory immune environment surrounding titanium bone implants determines the formation of osseointegration, and nanopatterning on implant...
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MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage
BackgroundUlcerative colitis (UC) is one chronic and relapsing inflammatory bowel disease. Macrophage has been reputed as one trigger for UC....
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Quantitative biochemical phenotypic heterogeneity of senescent macrophage at a single cell level by Synchrotron Radiation Fourier Transform Infrared Microspectroscopy
Macrophage senescence plays an important role in pathophysiological process of age-related diseases such as atherosclerosis, chronic obstructive...
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Softness enhanced macrophage-mediated therapy of inhaled apoptotic-cell-inspired nanosystems for acute lung injury
Engineered nanosystems offer a promising strategy for macrophage-targeted therapies for various diseases, and their physicochemical parameters...
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Lean adipose tissue macrophage derived exosome confers immunoregulation to improve wound healing in diabetes
Chronic non-healing wounds, a prevalent complication of diabetes, are associated with increased mortality in diabetic patients. Excessive...
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A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy
Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials...
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Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization
The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch...
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A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis
Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There is a pressing need for innovative OA therapies. While...
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Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization
Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery...
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Label-Free and Real-Time Electrical Impedance Monitoring of Macrophage Polarization of THP-1 Monocytes on Indium Tin Oxide Electrode
Macrophages are immune cells that play important roles in the human body’s initial immune responses against pathogens and tumor cells. We...
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Hydrophilic nanofibers with aligned topography modulate macrophage-mediated host responses via the NLRP3 inflammasome
Successful biomaterial implantation requires appropriate immune responses. Macrophages are key mediators involved in this process. Currently,...
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Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles
BackgroundMacrophages are highly plastic innate immune cells that play key roles in host defense, tissue repair, and homeostasis maintenance. In...
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Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles
Anti-tumor M1-like and pro-tumor M2-like tumor-associated macrophages (TAMs) coexist in tumor microenvironments (TME). The adverse effects of these...
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Phytol from Scoparia dulcis prevents NF-κB-mediated inflammatory responses during macrophage polarization
Macrophages are primary immune cells that mediate a wide range of inflammatory diseases through their polarization potential. In this study, phytol...
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Immunostimulatory activity of Hovenia dulcis branches extracts through TLR4/JNK-dependent macrophage activation and TLR4-dependent macrophage autophagy in RAW264.7 cells
Hovenia dulcis , one of the traditional medicinal plants, is currently being used as a functional ingredient for the development of health functional...
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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is...
